Mini seminar on Adverse Outcome Pathways (AOPs)

NIVA and The Norwegian Food Safety Authority hosts an open seminar; Dan Villeneuve (USEPA): 'An Introduction to Adverse Outcome Pathways' on October 25th.

Dan Villeneuve (USEPA): An Introduction to Adverse Outcome Pathways

25.10.2016, 09:00 - 11:00, FAROS, CIENS Toppsenter, Oslo Science Park.

Adverse outcome pathways (AOPs) are a conceptual framework for organizing existing information concerning the predictive linkages between the initiation or early progression of a biological perturbation in an organism and the adverse outcome(s) of regulatory relevance (e.g., negative human health outcomes or impacts on survival, growth, or reproduction in wildlife) that the perturbation can lead to. Consequently, the organization of biological and toxicological knowledge into AOP frameworks has been advocated as a means to support so called “21st century” approaches to regulatory decision-making which aim to make greater use of mechanistic or pathway-based data as a basis for chemical safety assessment. In order to facilitate the development of AOPs and their practical application to environmental decision-making the Organization for Economic Cooperation and Development (OECD), through the activities of its member countries, has developed internationally harmonized guidance and a knowledge-base for capturing and disseminating AOP descriptions. The goal of this training is to facilitate greater awareness the adverse outcome pathway knowledgebase and associated guidance, principles, and practice of AOP development and description, so that the scientific community can more effectively contribute to and utilize this emerging resource.


  • Introduction to AOPs  - what are they, what are they good for?
  • Principles of AOP development
  • Introduction to the AOP knowledgebase
    • Structure and content
    • Weight of evidence assembly and evaluation – the how and why.

Organisers:  Knut Erik Tollefsen (NIVA) and Hanne Marit Gran (Norwegian Food Safety Authority)

Registration: Seminar is free and only require registration to before October 10. Seats are offered on a first come- first served basis.  Light refreshments will be served.

Sist oppdatert 28.09.2016