Publications directly related to the project activity

Evenseth, L.M., Kristiansen, K., Tollefsen, K.E. Sylte, I. (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Comp. Toxicol. 12: doi:

Miyakawa, H., Song, Y., Tollefsen, K.E., Iguchi, T. (2018). Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. J. Steroid Biochem. Mol. Biol.

Song, Y., Villeneuve, D.; Toyota, K.; Iguchi, T., Tollefsen, K.E.  (2017a). Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development. Environ. Sci. Technol., Critical reviews. 51 (8): 4142–4157

Song, Y., Evenseth, L.M., Iguchi, T., Knut Erik Tollefsen (2017b). Release of chitobiase as an indicator of potential molting disruption in juvenile Daphnia magna exposed to ecdysone receptor agonists Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 954-962.

Fay, K.A., Villeneuve, D.L., Lalone, C.A. Song, Y., Tollefsen, K.E., Ankley, G.T. (2017).  Practical approaches to adverse outcome pathway (AOP) development and weight of evidence evaluation as illustrated by ecological case studies. Environ. Toxicol. Chem. 36(6):1429-1449.

Miyakawa, H. and Iguchi, T. (2017). Comparative luciferase assay for establishing reliable in vitro screening system of juvenile hormone agonists J. Appl. Toxicol., 37, 1082-1090.

Toyota, K., Sato, T., Tatarazako, N. and Iguchi, T. (2017). Photoperiodism of male offspring production in the water flea Daphnia pulex. Zool. Sci., 34, 312-317.

Song, Y., Rundberget, J.T., Evenseth, L., Xie, L. Gomes, T., Høgåsen, T. Iguchi, T. Tollefsen, K.E. (2016). Whole-organism transcriptomic analysis provides mechanistic insight into the acute toxicity of emamectin benzoate in Daphnia magna. Environ. Science Technol. 50(21):11994-12003.

LaLone, C. A.; Villeneuve, D. L.; Lyons, D.; Helgen, H. W.; Robinson, S. L.; Swintek, J. A.; Saari, T. W.; Ankley, G. T., (2016) Editor's Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A web-based tool for addressing the challenges of cross-species extrapolation of chemical toxicity. Toxicol. Sci. 153, (2), 228-45.

Sumiya, E., Ogino, Y., Toyota, K., Miyakawa, H., Miyagawa, S. and Iguchi, T. (2016). Neverland regulates embryonic moltings through the regulation of ecdysteroid synthesis in the water flea Daphnia magna, and may thus act as a target for chemical disruption of molting. J. Appl. Toxicol., 36(11):1476-85.

Abe, R, Toyota, K., Miyakawa, H., Watanabe,H., Okad, T., Miyagaw, S. Nishide, H., Uchiyamae, I., Tollefsen, K.E., Iguchi, T., Tatarazakoa, N. (2015) Comparison between TG211 ANNEX 7 and short-term screening assay for detecting male offspring production in Daphnia magna using diofenolan. Aquatic toxicology.159: 44-51

Toyota, K., Miyakawa, H., Yamaguchi, K., Shigenobu, S., Ogino, Y., Tatarazako, N., Miyagawa, S. and Iguchi, T. (2015a). NMDA receptor activation on the upstream of methyl farnesoate signaling for short-day induced male offspring production in water flea Daphnia pulex. BMC Genomics, 16, 186.

Toyota, K., Miyakawa, H., Hiruta, C., Furuta, K., Ogino, Y., Shinoda, T., Tatarazako, N., Miyagawa, S., Shaw, J.R. and Iguchi, T. (2015b). Methyl farnesoate synthesis is necessary for the environmental sex determination in the water flea Daphnia pulex. J. Insect Physiol., 80, 22-30.

Mellor, C.L., Cronin, M.T.,  Evenseth, L.M.,  Sylte, I.,  Kristiansen, K., Tollefsen, K.E. (2014). Integrating Computational Modelling of Receptor Binding into Mechanistically-Based Risk Assessment for Endocrine Disruptors. Toxicology Letters 229, Supplement: S162-S163.

Sumiya, E., Ogino Y., Miyakawa, H., Hiruta, C., Toyota, K., Miyagawa, S. and Iguchi, T. (2014). Roles of ecdysteroids for progression of reproductive cycle in the fresh water crustacean Daphnia magna. Front. Zool., 11, 60.

Publications from workshops

Bridges, J., Sauer, U.G., Buesen, R., Deferme, L., Tollefsen, K.E., Tralau, T., van Ravenzwaay, B., Poole, A., Pemberton, M. (2017). Framework for the quantitative weight-of-evidence analysis of ‘omics data for regulatory purposes. Regul Toxicol Pharmacol. 91: S46-S60.

Gant, T.W., Sauer, U.G., Zhang, S.D., Chorley, B.N., Hackermüller, J., Perdichizzi, S., Tollefsen, K.E., van Ravenzwaay, B., Yauk, C., Tong, W., Poole, A. (2017). A generic Transcriptomics Reporting Framework (TRF) for ‘Omics Data Processing and Analysis. Regul Toxicol Pharmacol. 91: S36-S45

Kauffmann, H.M., Fuchs, R., Chorley, B.N., Deferme, L., Ebbels, T., Hackermüller, J., Perdichizzi, S. Poole, A. Sauer, U.G., Tollefsen, K.E., Tralau, T., Yauk, C., van Ravenzwaay, B. (2017). Framework for the quality assurance of ’omics technologies considering GLP requirements. Regul Toxicol Pharmacol. 91: S27-S36

Buesen, R., Chorley, B.N., da Silva Lima, B., Daston, G., Deferme, L., Ebbels, T., Gant. T.W., Goetz, A., Greally, J., Gribaldo, L., Hackermüller, J., Hubesch, B., Jennen, D., Johnson, K., Kanno, J., Kauffmann, H.M., Laffont, M. Meehan, R., Pemberton, M., Perdichizzi1, S., Piersma, A.H., Sauer, U.G., Schmidt, K., Seitz, H., Sumida, K., Tollefsen, K.E., Tong, W., Tralau, T., van Ravenzwaay, B., Weber, R., Worth, A., Yauk, C., Poole, A. (2017). Applying ‘omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regul Toxicol Pharmacol. 91: S3-S13.

Brockmeier, E., Hodges, G., Hutchinson, T.H., Butler, E., Hecker, M., Tollefsen, K.E., Garcia-Reyero, N., Kille, P., Becker, D., Chipman, K., Colbourne, J., Collette, T., Cossins, A., Cronin , M., Graystock, P., Gutsell, S., Knapen, D., Katsiadaki, I., Lange, A., Marshall, S. Owen, S., Perkins, E.J., Plaistow, S., Schroeder, A:, Taylor, D., Viant, M., Ankley, G., Falciani, F. (2017). The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment. Toxicological Sciences. 158 (2): 252-262. doi: 10.1093/toxsci/kfx097.

Groh, K., and Tollefsen, K.E. (2015). The Challenge: Adverse outcome pathways in research and regulation—Current status and future perspectives. Environ. Toxicol. Chem. 34: 1935-1936.

Garcia-Reyero, N. (2015). Are adverse outcome pathways here to stay? Environmental Science & Technology 2015; 49: 3-9.

Tollefsen KE, Scholz S, Cronin MT, Edwards SW, de Knecht J, Crofton K, et al. (2014). Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA). Regulatory Toxicology and Pharmacology 2014; 70: 629-640.

Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, et al. (2014a). Adverse outcome pathway (AOP) development I: strategies and principles. Toxicol Sci; 142: 312-20.

Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, et al. (2014b). Adverse outcome pathway development II: best practices. Toxicol Sci 2014; 142: 321-30.

Last updated 04.07.2019