Publications

Wolf, R. and Tollefsen, K.E. (2021). A bayesian approach to incorporating spatiotemporal variation and uncertainty limits into modeling of predicted environmental concentrations from chemical monitoring campaigns. Environ. Sci. Technol. 55(3): 1699-1709 doi:10.1021/acs.est.0c06268

Moe, S.J., Wolf, R., Xie, L., Landis, W.G., Kotamäki, N., Tollefsen, K.E. (2021). Quantification of an Adverse Outcome Pathway network by Bayesian regression and Bayesian network modelling. Integrated Environmental Assessment and Management (IEAM), 17: 147-164. doi.org/10.1002/ieam.4348

Xie, L., Solhaug, K.A., Song, Y., Johnsen, B, Tollefsen, K.E. (2020). Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta. 252: 86. doi.org/10.1007/s00425-020-03482-3

Song, Y., Xie, L., Lee, Y.K., Tollefsen, K.E. (2020). De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environ. Sci. Technol. 54(20): 13147-13156. doi.org/10.1021/acs.est.0c03794.

Thaulow, J., Song, Y., Lindeman, L.C., Kamstra, J.H., Lee, Y., Xie, L., Aleström, P., Salbu, B., Tollefsen, K.E. (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research. 190: 109930. doi.org/10.1016/j.envres.2020.109930

Mellor, C.L., Tollefsen, K.E., Lalone, C., Cronin, M.T.D. and Firman, J.W. (2020). In silico identification of chemicals capable of binding to the ecdysone receptor. Environ. Toxciol.Chem. 39 (7): 1438-1450. doi.org/10.1002/etc.4733

Song, Y., Xi, L., Lee, Y. Brede, D.A., Lyne, F., Kassaye, Y., Thaulow, J., Caldwell, G., Salbu, B., Tollefsen, K.E. (2020). Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment.705: 135912. doi.org/10.1016/j.scitotenv.2019.135912

Moe, S.J., Hjermann, D.Ø., Ravagnan, E., Bechmann, R.B. (2019). Effects of an aquaculture pesticide (diflubenzuron) on non-target shrimp populations: extrapolation from laboratory experiments to the risk of population decline. Ecological Modelling. 413: 108833. doi.org/10.1016/j.ecolmodel.2019.108833

Schirmer, K., Stadnicka, J., Belanger, S. Blaha, L., Bols, N., Dyer, S: Embry, M., Fischer, M., Halder, M., Hermens, J., Hultman, M.T.,  Kramer, N., Laue, H., Lee, L., Lillicrap, A, Natsch, A. Segner, H., Tanneberger, K., Tollefsen, K.E., Werner, I., Witters, H., and Zupanic, A. (2019). Cell-based data to predict the toxicity of chemicals to fish. Commentary on the manuscript by Rodrigues et al., 2019. Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides. Environmental Pollution 252:476-482. doi.org/10.1016/j.envpol.2019.113060

Faust, M., Backhaus, T., Altenburger, R., Dulio, V., van Gils, J., Ginebreda, A., Kortenkamp, A:, Munthe, J., Posthuma, L., Slobodnik, J., Tollefsen, K.E., van Wezel, A. amd Brack, W. (2019). Prioritisation of water pollutants. The EU Project SOLUTIONS proposes a methodological framework for the integration of mixture risk assessments into prioritisation procedures under the European Water Framework Directive.  Environ Sci Eur. 31: 66-70. doi.org/10.1186/s12302-019-0239-4

Lindeman, L.C., Thaulow, J., Song, Y., Kamstra, J.H., Xie, Li., Asselman, J., Aleström, P., Tollefsen, K.E. (2019). Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics. 5.(3) s.dvz016. doi.org/10.1093/eep/dvz016

Blagojevic, D., Lee, Y.K., Xie, L., Brede, D.A., Nybakken, L., Lind, O.C., Tollefsen, K.E., Salbu, B., Solhaug, K.A., Olsen, J.E. (2019). No Evidence of a Protective or Cumulative Negative Effect of UV-B on Growth Inhibition Induced by Gamma Radiation in Scots Pine (Pinus Sylvestris) Seedlings. Photochemical & Photobiological Sciences. 18(8), 1945-1962. doi.org/10.1039/C8PP00491A

Evenseth, L.M., Kristiansen, K., Song, Y., Tollefsen, K.E. Sylte, I. (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Comp. Toxicol. 12: 100091.  doi.org/10.1016/j.comtox.2019.100091

Xie, L., Solhaug, K.A., Brede, D.A. Lind, O.C., Song, Y. Salbu, B., Tollefsen, K.E. (2019). Modes of action and adverse effects of gamma radiation in the aquatic macrophytes Lemna minor. Sci. Total. Environ. 680:23-34. doi.org/10.1016/j.scitotenv.2019.05.016

Salbu, B., Lind, O.C., Teien, H.C., Tollefsen, K.E. (2019). Why is the multiple stressor concept of relevance to radioecology? Int J. Rad Biol. 11:1-10. doi.org/10.1080/09553002.2019.1605463

Almeida, A.C., Gomes, T., Langford, K., Thomas, K.V., Tollefsen, K.E. (2019). Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquatic Toxicology. 210:117-128. doi.org/10.1016/j.aquatox.2019.02.021

Fischer, M., Belanger, S., Berckmans, P., Bernhard, M., Blaha, L.., Coman Schmid, D., Dyer, S., Haupt, T., Hermens, J., Hultman, M. T., Laue, H.; Lillicrap, A., Mlnaříková, M., Natsch, A., Novák, J.; Sinnige, T.; Tollefsen, K.E. von Niederhäusern, V., W, H., Zupanic, A., Schirmer, K. (2019). Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity. Tox. Sci. 169: 353-364. doi.org/10.1093/toxsci/kfz057

Song, Y., Nahrgang, J., Tollefsen, K.E. (2019). Transcriptomic analysis reveals dose-dependent toxic mechanisms of benzo(a)pyrene in polar cod (Boreogadus saida). Sci. Total. Environ. 653:176-189. doi.org/10.1016/j.scitotenv.2018.10.261

Hultman M.T, Løken K.B., Grung, M., Reid M. and Lillicrap A. (2019). Performance of 3D hepatic spheroids in a biotransformation study of Pyrene. Environmental Chemistry and Toxicology. 38(8):1738-1747. doi.org/10.1002/etc.4476

Moe, S.J., Hjermann, D.Ø., Ravagnan, E., Bechmann, R.B. (accepted). Effects of an aquaculture pesticide (diflubenzuron) on non-target shrimp populations: extrapolation from laboratory experiments to the risk of population decline. Ecological Modelling. doi.org/10.1016/j.ecolmodel.2019.108833

Hevrøy, T. H., Golz, A. L., Xie, L., Hansen, E. L., & Bradshaw, C.,2019. Radiation effects and ecological processes in a freshwater microcosm. Journal of environmental radioactivity. 203: 71-83. doi.org/10.1016/j.jenvrad.2019.03.002

Myklebust E.B., Jimenez-Ruiz E., Chen J., Wolf R., Tollefsen, K.E., 2019. Knowledge Graph Embedding for Ecotoxicological Effect Prediction. Int’l Sem. Web Conf. (ISWC), LNCS 11779 doi.org/10.1007/978-3-030-30796-7_30

Myklebust, E.B., Jimenez-Ruiz, E., Chen, J., Wolf, R., Tollefsen, K.E. (2019) Knowledge graph embedding for ecotoxicological effect prediction. CEUR Workshop Proceedings 2019 ; Volume 2456.(10) s. 37-40 arxiv.org/abs/1907.01328

Song, Y., Nahrgang, J., Tollefsen, K.E. (2019). Transcriptomic analysis reveals dose-dependent toxic mechanisms of benzo(a)pyrene in polar cod (Boreogadus saida). Sci. Total. Environ. 653:176-189. doi.org/10.1016/j.scitotenv.2018.10.261

Lindeman, L.C. Thaulow, J., Song, Y. Kamstra, J.H., Xie, L. Asselman, J., Aleström, P., Tollefsen, K.E. (2019). Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics 2019 ;Volum 5.(3) s.dvz016. doi.org/10.1093/eep/dvz016

Tousova, S., Froment, J., Oswald, P., Thomas, K.V., Tollefsen, K.E., Reid, M., Langford, K., Slobodník, J., Hilscherova, K., Blaha, L. (2018) Identification of algal growth inhibitors in treated wastewater using effect-directed analysis based on non-target screening techniques. J. of Maz. Mat., 358: 494-502. doi.org/10.1016/j.jhazmat.2018.05.031

Hiruta, C., Kakui, K., Tollefsen, K.E., Iguchi,T (2018). Targeted gene disruption by use of CRISPR/Cas9 ribonucleoprotein complexes in the water flea Daphnia pulex. Genes to Cells. 23:494-502. doi.org/10.1111/gtc.12589

Altenburger, R., Escher, B., Jakobs, G., Krauss, M., Krüger, J., Neale, P., Ait-Aissa, S., Almeida, A.C., Seiler, T.B., Brion, F., Hilscherova, K., Hollert, H., Novak, J., Schlichting, R., Serra, H., Peng, Y., Tindall, A., Tollefsen, K.E., Umbuzeiro, G., Williams, T., Kortenkamp, A., Scholze, M. (2018). Mixture effect detection in complex contaminated samples – an interlaboratory comparative study using effect-based methods. Environment International. 114: 95-106. doi.org/10.1016/j.envint.2018.02.013

Song, Y., Asselman, J., De Schamphelaere, K.A.C., Salbu, B., Tollefsen, K.E. (2018). Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: a Conceptual Approach. Environ. Sci. Technol. 52: 5479-5489. doi.org/10.1021/acs.est.8b00749

Gomes, T., Song, Y., Brede, D.A., Xie, L., Gutkzow, K.B., Salbu, B., Tollefsen, K.E. (2018). Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Sci. Total Environ. 628-629: 206-216. doi: 10.1016/j.scitotenv.2018.02.039.

Xie, L., Gomes, T., Solhaug, K.A., Song, Y., Tollefsen, K.E. (2018). Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. Aquatic Toxicology. 197: 98-108. doi.org/10.1016/j.aquatox.2018.02.005

Miyakawaa, H., Song, Y., Tollefsen, K.E., Iguchi, T. (2017). Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. J Steroid Biochem Mol Biol. pii: S0960-0760(17), 30370-30379 doi.org/10.1016/j.jsbmb.2017.12.006

Bridges, J., Sauer, U.G., Buesen, R., Deferme, L., Tollefsen, K.E., Tralau, T., van Ravenzwaay, B., Poole, A., Pemberton, M. (2017). Framework for the quantitative weight-of-evidence analysis of ‘omics data for regulatory purposes. Regul Toxicol Pharmacol. 91: S46-S60. doi.org/10.1016/j.yrtph.2017.10.010

Gant, T.W., Sauer, U.G., Zhang, S.D., Chorley, B.N., Hackermüller, J., Perdichizzi, S., Tollefsen, K.E., van Ravenzwaay, B., Yauk, C., Tong, W., Poole, A. (2017). A generic Transcriptomics Reporting Framework (TRF) for ‘Omics Data Processing and Analysis. Regul Toxicol Pharmacol. 91: S36-S45 doi.org/10.1016/j.yrtph.2017.10.010

Kauffmann, H.M., Fuchs, R., Chorley, B.N., Deferme, L., Ebbels, T., Hackermüller, J., Perdichizzi, S. Poole, A. Sauer, U.G., Tollefsen, K.E., Tralau, T., Yauk, C., van Ravenzwaay, B. (2017). Framework for the quality assurance of ’omics technologies considering GLP requirements. Regul Toxicol Pharmacol. 91: S27-S36 doi.org/10.1016/j.yrtph.2017.10.007

Buesen, R., Chorley, B.N., da Silva Lima, B., Daston, G., Deferme, L., Ebbels, T., Gant. T.W., Goetz, A., Greally, J., Gribaldo, L., Hackermüller, J., Hubesch, B., Jennen, D., Johnson, K., Kanno, J., Kauffmann, H.M., Laffont, M. Meehan, R., Pemberton, M., Perdichizzi1, S., Piersma, A.H., Sauer, U.G., Schmidt, K., Seitz, H., Sumida, K., Tollefsen, K.E., Tong, W., Tralau, T., van Ravenzwaay, B., Weber, R., Worth, A., Yauk, C., Poole, A. (2017). Applying ‘omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regul Toxicol Pharmacol. 91: S3-S13 doi.org/10.1016/j.yrtph.2017.09.002

Tollefsen, K.E. and Kacew, S. (2017). 6th Norwegian Environmental Toxicology symposium: Assessing and solving environmental challenges in a multiple stressor world. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 805-806. doi.org/10.1080/15287394.2017.1352159

Almeida, A.C., Petersen, K., Langford, K., Thomas, K.V. and Tollefsen, K.E. (2017). Toxicity of biocides on the growth and PSII efficiency of Chlamydomonas reinhardtii. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 971-986. doi.org/10.1080/15287394.2017.1352176

Hultman, M.T., Petersen, K., Tollefsen, K.E. (2017). Characterizing combined effects of antiestrogenic chemicals on vitellogenin production in rainbow trout (Oncorhynchus mykiss) hepatocytes. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 987-1001. doi.org/10.1080/15287394.2017.1354435

Petersen, K., Hultman, M.T., Bytingsvik, J., Harju, M., Evenset, A., Tollefsen, K.E. (2017). Characterizing cytotoxic and estrogenic activity of Arctic char tissue extracts in primary Arctic char hepatocytes. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 1017-1030. doi.org/10.1080/15287394.2017.1357277

Song, Y., Evenseth, L.M., Iguchi, T., Knut Erik Tollefsen (2017). Release of chitobiase as an indicator of potential molting disruption in juvenile Daphnia magna exposed to ecdysone receptor agonists Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 954-962. doi.org/10.1080/15287394.2017.1352215

Tollefsen, K.E., Song, Y., Høgåsen, T., Øverjordet, I.B., Altin, D., Hansen, B.H. (2017). Acute and sublethal toxicity of mercury to the marine copepod Calanus finmarchicus. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 845-861. doi.org/10.1080/15287394.2017.1352198

Petersen, K., Hultman, M.T., Rowland, S., Tollefsen, K.E. (2017). Toxicity of organic compounds from unresolved complex mixtures (UCMs) to primary fish hepatocytes. Aquatic Toxicology. 190:150-161. doi.org/10.1016/j.aquatox.2017.06.007

Tousova, Z, Oswald, P., Slobodnik, J., Muz, M., Hu, H., Brack, W., Krauss, M., Koprivica, S., Ahel, M., Schollee, J., Hidasi, A., Hollender, J., Schirmer, K-, Suter, M.J.F., Sonavane, M., Ait-Aissa, S:, Creusot, N., Brion, F., Di Paolo, C., Seiler, T.B., Hollert, H., Froment, J., Almeida, A.C., Thomas, K.V., Tollefsen, K.E., m Tufi, S., Ouyang, X., Leonards, P., Lamoree, M., Torrens, V.O., Schriks, M., Kolkman, A.M., Spirhanzlova, P., Tindall, A., Blaha, L., Schulze, T. (2017). EDA-EMERGE – European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants with adverse effect potential in European surface waters. Sci. Total. Environ. 601-602: 1849-1868. doi.org/10.1016/j.scitotenv.2017.06.032

Almeida, A.C., Gomes, T. Langford, K., Thomas, K.V., Tollefsen, K.E. (2017). Oxidative stress in the algae Chlamydomonas reinhardtii exposed to biocides. Aquatic Toxicology. 189: 50-59. doi.org/10.1016/j.aquatox.2017.05.014

Brockmeier, E., Hodges, G., Hutchinson, T.H., Butler, E., Hecker, M., Tollefsen, K.E., Garcia-Reyero, N., Kille, P., Becker, D., Chipman, K., Colbourne, J., Collette, T., Cossins, A., Cronin , M., Graystock, P., Gutsell, S., Knapen, D., Katsiadaki, I., Lange, A., Marshall, S. Owen, S., Perkins, E.J., Plaistow, S., Schroeder, A:, Taylor, D., Viant, M., Ankley, G., Falciani, F. (2017). The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment. Toxicological Sciences. 158 (2): 252-262. doi.org/10.1093/toxsci/kfx097

Neale, P. A., Altenburger, R., Ait-Aissa, S., Brion, F., Busch, W., de Aragao Umbuzeiro, G., Denison, M. S., Du Pasquier, D. Hilscherova, K., Hollert, H., Morales, D. A. Novak, J. ., Schlichting, R. . Seiler, T. B., Serra, H., Shao, Y., Tindall, A. J., Tollefsen, K. E. Williams, T. D. and B. I. Escher (2017). Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water, Water Res, 123: 734-50. doi.org/10.1016/j.watres.2017.07.016

Fay, K.A., Villeneuve, D.L., Lalone, C.A. Song, Y., Tollefsen, K.E., Ankley, G.T. (2017). Practical approaches to adverse outcome pathway (AOP) development and weight of evidence evaluation as illustrated by ecological case studies. Environ. Toxicol. Chem. 36(6):1429-1449. doi.org/10.1002/etc.3770

Song, Y., Villeneuve, D.; Toyota, K.; Iguchi, T., Tollefsen, K.E. (2017). Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development. Environ. Sci. Technol., Critical reviews. 51 (8): 4142–4157 doi.org/10.1021/acs.est.7b00480

Petersen, K., Hultman, M., Tollefsen, K.E. (2017). Primary hepatocytes from Arctic char (Salvelinus alpinus) as an environmentally relevant Arctic in vitro model for screening contaminants and environmental extracts. Aquatic toxicology.187: 141–152. doi.org/10.1016/j.aquatox.2017.03.023

Schulze, T., Ahel, M., Ahlheim, J., Aït-Aïssa, S., Brion, F., Di Paolo, C., Froment, J., Hidasi, A.O., Hollender, J., Hollert, H., Hu, M., Kloß, A., Koprivica, S., Krauss, M., Muz, M., Petre, M., Oswald, P., Schollée; J.E. Seiler, T.B., Shao, Y., Slobodnik, J., Sonavane, M., Suter, M., Tousova, Z., Tollefsen, K.E., Walz, K.H., Brack, W. (2017). Assessment of a novel device for onsite integrative large-volume solid phase extraction of water samples to enable a comprehensive chemical and effect-based analysis. Sci. Total Environment. 581-582: 350–358. doi.org/10.1016/j.scitotenv.2016.12.140

Ouyang, X., Froment, J., Leonards, P. E.G., Christiensen, G., Tollefsen, K.E., de Boer, J., Thomas, K.V., Lamoree, M.H. (2017). Miniaturization of a transthyretin binding assay using a fluorescent probe for high throughput screening of thyroid hormone disruption in environmental samples. Chemosphere. 171: 722–728. doi.org/10.1016/j.chemosphere.2016.12.119

Gomes, T., Xie, L., Brede, D., Lind, O.C., Solhaug, K.A., Salbu, B., Tollefsen, K.E. (2017). Sensitivity of the green algae Chlamydomonas reinhardtii to ionizing (gamma) radiation: photosynthetic performance and ROS formation. Aquatic Toxicology. 183:1-10. doi.org/10.1016/j.aquatox.2016.12.001

Last updated 16.02.2021