Xie, L., Macken, A., Johnsen, B., Norli, M., Skogan, O.A.S., Tollefsen, K.E. (2022). The MicroClimate Screen – A microscale climate exposure system for assessing the effect of CO2, temperature and UV on marine microalgae. Marine Environmental Research 179:105670.  

Chauhan, V., Beaton, D., Hamada, N., Wilkins, R., Burtt, J., Leblanc, J., Cool, D., Garnier-Laplace, J., Laurier, D., Le, Y., Yamada, Y., Tollefsen, K.E. (2022). Adverse Outcome Pathway: A Path towards better Data Consolidation and Global Co-ordination of Radiation Research. International Journal of Radiation Biology 7: 1-10.

Toyota, K., Watanabe, H., Hirano, M., Abe, R., Miyakawa, H., Song, Y., Sato, T., Miyagawa, S., Tollefsen, K.E., Yamamoto, H., Tatarazako, N., Iguchi, T. (2022). Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology 243: 106058.

Grung, M., Meland, S., Ruus, A., Ranneklev, S., Fjeld, E., Kringstad, A., Rundberget, J.T., Cruz, Majbrit D., Christensen, J.H. (2021). Occurrence and trophic transport of organic compounds in sedimentation ponds for road runoff. Science of the Total Environment 751: 141808.

Kjær, C., Sørensen, P.B., Wiberg-Larsen, P., Bak, J., Bruus, M., Strandberg, B., Larsen, S.E. Rasmussen, J.J., Strandberg, M. (2021). Vulnerability of Aquatic Insect Species to Insecticides, Depending on Their Flight Period and Adult Life Span. Environmental Toxicology and Chemistry 40: 1778-1787.

Lerebours, A., Murzina, S., Song, Y., Tollefsen, K.E., Benedetti, M., Regoli, F., Rotchell, J.M., Nahrgang, J. (2021). Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research 170: 105434.

Moe, S.J.., Carriger, J.F., Glendell, M. (2021). Increased Use of Bayesian Network Models Has Improved Environmental Risk Assessments. Integrated Environmental Assessment and Management 17: 53-61.

Moe, S.J., Wolf, R., Xie, L., Landis, W.G., Kotamäki, N., Tollefsen, K.E. (2021). Quantification of an Adverse Outcome Pathway network by Bayesian regression and Bayesian network modelling. Integrated Environmental Assessment and Management 17: 147-164.

Scheibener, S., Song, Y., Tollefsen, K.E., Salbu, B., Teien, H.C. (2021). Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology 235: 105836.

Schmid, S., Song, Y., Tollefsen, K.E. (2021). AOP report: Inhibition of Chitin Synthase 1 leading to Increased Mortality in Arthropods. Environmental Toxicology and Chemistry. Pathways and predictions. 40: 2112–2120.

Song, Y., Kamstra, J.H., Cao, Y., Asselman, J., Anglès d'Auriac, M., Friberg, N. (2021). High-throughput analyses and Bayesian network modeling highlight novel epigenetic Adverse Outcome Pathway networks of DNA methyltransferase inhibitor mediated transgenerational effects. Journal of Hazardous Materials 408: 124490.

Song, Y., Villenueve, D.L. (2021). AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation. Environmental Toxicology and Chemistry 40: 2959-2967.

Steindal, E. H., Grung, M. (2021). Management of PFAS with the aid of chemical product registries—an indispensable tool for future control of hazardous substances. Integrated Environmental Assessment and Management 17: 835-851.

Wiberg-Larsen, P., Nørum, U., Rasmussen, J.J. (2021). Repeated insecticide pulses increase harmful effects on stream macroinvertebrate biodiversity and function. Environmental Pollution 273: 116404.

Wolf, R., Tollefsen, K.E. (2021). A Bayesian approach to incorporating spatiotemporal variation and uncertainty limits into modeling of predicted environmental concentrations from chemical monitoring campaigns. Environmental Science and Technology 55: 1699-1709.

Xie, L., Solhaug, K.A., Song, Y., Johnsen, B, Tollefsen, K.E. (2020). Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta. 252: 86.

Song, Y., Xie, L., Lee, Y.K., Tollefsen, K.E. (2020). De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environ. Sci. Technol. 54(20): 13147-13156.

Thaulow, J., Song, Y., Lindeman, L.C., Kamstra, J.H., Lee, Y., Xie, L., Aleström, P., Salbu, B., Tollefsen, K.E. (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research. 190: 109930.

Mellor, C.L., Tollefsen, K.E., Lalone, C., Cronin, M.T.D. and Firman, J.W. (2020). In silico identification of chemicals capable of binding to the ecdysone receptor. Environ. Toxciol.Chem. 39 (7): 1438-1450.

Song, Y., Xi, L., Lee, Y. Brede, D.A., Lyne, F., Kassaye, Y., Thaulow, J., Caldwell, G., Salbu, B., Tollefsen, K.E. (2020). Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment.705: 135912.

Moe, S.J., Hjermann, D.Ø., Ravagnan, E., Bechmann, R.B. (2019). Effects of an aquaculture pesticide (diflubenzuron) on non-target shrimp populations: extrapolation from laboratory experiments to the risk of population decline. Ecological Modelling. 413: 108833.

Schirmer, K., Stadnicka, J., Belanger, S. Blaha, L., Bols, N., Dyer, S: Embry, M., Fischer, M., Halder, M., Hermens, J., Hultman, M.T.,  Kramer, N., Laue, H., Lee, L., Lillicrap, A, Natsch, A. Segner, H., Tanneberger, K., Tollefsen, K.E., Werner, I., Witters, H., and Zupanic, A. (2019). Cell-based data to predict the toxicity of chemicals to fish. Commentary on the manuscript by Rodrigues et al., 2019. Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides. Environmental Pollution 252:476-482.

Faust, M., Backhaus, T., Altenburger, R., Dulio, V., van Gils, J., Ginebreda, A., Kortenkamp, A:, Munthe, J., Posthuma, L., Slobodnik, J., Tollefsen, K.E., van Wezel, A. amd Brack, W. (2019). Prioritisation of water pollutants. The EU Project SOLUTIONS proposes a methodological framework for the integration of mixture risk assessments into prioritisation procedures under the European Water Framework Directive.  Environ Sci Eur. 31: 66-70.

Lindeman, L.C., Thaulow, J., Song, Y., Kamstra, J.H., Xie, Li., Asselman, J., Aleström, P., Tollefsen, K.E. (2019). Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics. 5.(3) s.dvz016.

Blagojevic, D., Lee, Y.K., Xie, L., Brede, D.A., Nybakken, L., Lind, O.C., Tollefsen, K.E., Salbu, B., Solhaug, K.A., Olsen, J.E. (2019). No Evidence of a Protective or Cumulative Negative Effect of UV-B on Growth Inhibition Induced by Gamma Radiation in Scots Pine (Pinus Sylvestris) Seedlings. Photochemical & Photobiological Sciences. 18(8), 1945-1962.

Evenseth, L.M., Kristiansen, K., Song, Y., Tollefsen, K.E. Sylte, I. (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Comp. Toxicol. 12: 100091.

Xie, L., Solhaug, K.A., Brede, D.A. Lind, O.C., Song, Y. Salbu, B., Tollefsen, K.E. (2019). Modes of action and adverse effects of gamma radiation in the aquatic macrophytes Lemna minor. Sci. Total. Environ. 680:23-34.

Salbu, B., Lind, O.C., Teien, H.C., Tollefsen, K.E. (2019). Why is the multiple stressor concept of relevance to radioecology? Int J. Rad Biol. 11:1-10.

Almeida, A.C., Gomes, T., Langford, K., Thomas, K.V., Tollefsen, K.E. (2019). Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquatic Toxicology. 210:117-128.

Fischer, M., Belanger, S., Berckmans, P., Bernhard, M., Blaha, L.., Coman Schmid, D., Dyer, S., Haupt, T., Hermens, J., Hultman, M. T., Laue, H.; Lillicrap, A., Mlnaříková, M., Natsch, A., Novák, J.; Sinnige, T.; Tollefsen, K.E. von Niederhäusern, V., W, H., Zupanic, A., Schirmer, K. (2019). Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity. Tox. Sci. 169: 353-364.

Song, Y., Nahrgang, J., Tollefsen, K.E. (2019). Transcriptomic analysis reveals dose-dependent toxic mechanisms of benzo(a)pyrene in polar cod (Boreogadus saida). Sci. Total. Environ. 653:176-189.

Hultman M.T, Løken K.B., Grung, M., Reid M. and Lillicrap A. (2019). Performance of 3D hepatic spheroids in a biotransformation study of Pyrene. Environmental Chemistry and Toxicology. 38(8):1738-1747.

Moe, S.J., Hjermann, D.Ø., Ravagnan, E., Bechmann, R.B. (accepted). Effects of an aquaculture pesticide (diflubenzuron) on non-target shrimp populations: extrapolation from laboratory experiments to the risk of population decline. Ecological Modelling.

Hevrøy, T. H., Golz, A. L., Xie, L., Hansen, E. L., & Bradshaw, C.,2019. Radiation effects and ecological processes in a freshwater microcosm. Journal of environmental radioactivity. 203: 71-83.

Myklebust E.B., Jimenez-Ruiz E., Chen J., Wolf R., Tollefsen, K.E., 2019. Knowledge Graph Embedding for Ecotoxicological Effect Prediction. Int’l Sem. Web Conf. (ISWC), LNCS 11779

Myklebust, E.B., Jimenez-Ruiz, E., Chen, J., Wolf, R., Tollefsen, K.E. (2019) Knowledge graph embedding for ecotoxicological effect prediction. CEUR Workshop Proceedings 2019 ; Volume 2456.(10) s. 37-40

Song, Y., Nahrgang, J., Tollefsen, K.E. (2019). Transcriptomic analysis reveals dose-dependent toxic mechanisms of benzo(a)pyrene in polar cod (Boreogadus saida). Sci. Total. Environ. 653:176-189.

Lindeman, L.C. Thaulow, J., Song, Y. Kamstra, J.H., Xie, L. Asselman, J., Aleström, P., Tollefsen, K.E. (2019). Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics 2019 ;Volum 5.(3) s.dvz016.

Tousova, S., Froment, J., Oswald, P., Thomas, K.V., Tollefsen, K.E., Reid, M., Langford, K., Slobodník, J., Hilscherova, K., Blaha, L. (2018) Identification of algal growth inhibitors in treated wastewater using effect-directed analysis based on non-target screening techniques. J. of Maz. Mat., 358: 494-502.

Hiruta, C., Kakui, K., Tollefsen, K.E., Iguchi,T (2018). Targeted gene disruption by use of CRISPR/Cas9 ribonucleoprotein complexes in the water flea Daphnia pulex. Genes to Cells. 23:494-502.

Altenburger, R., Escher, B., Jakobs, G., Krauss, M., Krüger, J., Neale, P., Ait-Aissa, S., Almeida, A.C., Seiler, T.B., Brion, F., Hilscherova, K., Hollert, H., Novak, J., Schlichting, R., Serra, H., Peng, Y., Tindall, A., Tollefsen, K.E., Umbuzeiro, G., Williams, T., Kortenkamp, A., Scholze, M. (2018). Mixture effect detection in complex contaminated samples – an interlaboratory comparative study using effect-based methods. Environment International. 114: 95-106.

Song, Y., Asselman, J., De Schamphelaere, K.A.C., Salbu, B., Tollefsen, K.E. (2018). Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: a Conceptual Approach. Environ. Sci. Technol. 52: 5479-5489.

Gomes, T., Song, Y., Brede, D.A., Xie, L., Gutkzow, K.B., Salbu, B., Tollefsen, K.E. (2018). Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Sci. Total Environ. 628-629: 206-216. doi: 10.1016/j.scitotenv.2018.02.039.

Xie, L., Gomes, T., Solhaug, K.A., Song, Y., Tollefsen, K.E. (2018). Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. Aquatic Toxicology. 197: 98-108.

Miyakawaa, H., Song, Y., Tollefsen, K.E., Iguchi, T. (2017). Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. J Steroid Biochem Mol Biol. pii: S0960-0760(17), 30370-30379

Bridges, J., Sauer, U.G., Buesen, R., Deferme, L., Tollefsen, K.E., Tralau, T., van Ravenzwaay, B., Poole, A., Pemberton, M. (2017). Framework for the quantitative weight-of-evidence analysis of ‘omics data for regulatory purposes. Regul Toxicol Pharmacol. 91: S46-S60.

Gant, T.W., Sauer, U.G., Zhang, S.D., Chorley, B.N., Hackermüller, J., Perdichizzi, S., Tollefsen, K.E., van Ravenzwaay, B., Yauk, C., Tong, W., Poole, A. (2017). A generic Transcriptomics Reporting Framework (TRF) for ‘Omics Data Processing and Analysis. Regul Toxicol Pharmacol. 91: S36-S45

Kauffmann, H.M., Fuchs, R., Chorley, B.N., Deferme, L., Ebbels, T., Hackermüller, J., Perdichizzi, S. Poole, A. Sauer, U.G., Tollefsen, K.E., Tralau, T., Yauk, C., van Ravenzwaay, B. (2017). Framework for the quality assurance of ’omics technologies considering GLP requirements. Regul Toxicol Pharmacol. 91: S27-S36

Buesen, R., Chorley, B.N., da Silva Lima, B., Daston, G., Deferme, L., Ebbels, T., Gant. T.W., Goetz, A., Greally, J., Gribaldo, L., Hackermüller, J., Hubesch, B., Jennen, D., Johnson, K., Kanno, J., Kauffmann, H.M., Laffont, M. Meehan, R., Pemberton, M., Perdichizzi1, S., Piersma, A.H., Sauer, U.G., Schmidt, K., Seitz, H., Sumida, K., Tollefsen, K.E., Tong, W., Tralau, T., van Ravenzwaay, B., Weber, R., Worth, A., Yauk, C., Poole, A. (2017). Applying ‘omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regul Toxicol Pharmacol. 91: S3-S13

Tollefsen, K.E. and Kacew, S. (2017). 6th Norwegian Environmental Toxicology symposium: Assessing and solving environmental challenges in a multiple stressor world. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 805-806.

Almeida, A.C., Petersen, K., Langford, K., Thomas, K.V. and Tollefsen, K.E. (2017). Toxicity of biocides on the growth and PSII efficiency of Chlamydomonas reinhardtii. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 971-986.

Hultman, M.T., Petersen, K., Tollefsen, K.E. (2017). Characterizing combined effects of antiestrogenic chemicals on vitellogenin production in rainbow trout (Oncorhynchus mykiss) hepatocytes. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 987-1001.

Petersen, K., Hultman, M.T., Bytingsvik, J., Harju, M., Evenset, A., Tollefsen, K.E. (2017). Characterizing cytotoxic and estrogenic activity of Arctic char tissue extracts in primary Arctic char hepatocytes. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 1017-1030.

Song, Y., Evenseth, L.M., Iguchi, T., Knut Erik Tollefsen (2017). Release of chitobiase as an indicator of potential molting disruption in juvenile Daphnia magna exposed to ecdysone receptor agonists Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 954-962.

Tollefsen, K.E., Song, Y., Høgåsen, T., Øverjordet, I.B., Altin, D., Hansen, B.H. (2017). Acute and sublethal toxicity of mercury to the marine copepod Calanus finmarchicus. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 845-861.

Petersen, K., Hultman, M.T., Rowland, S., Tollefsen, K.E. (2017). Toxicity of organic compounds from unresolved complex mixtures (UCMs) to primary fish hepatocytes. Aquatic Toxicology. 190:150-161.

Tousova, Z, Oswald, P., Slobodnik, J., Muz, M., Hu, H., Brack, W., Krauss, M., Koprivica, S., Ahel, M., Schollee, J., Hidasi, A., Hollender, J., Schirmer, K-, Suter, M.J.F., Sonavane, M., Ait-Aissa, S:, Creusot, N., Brion, F., Di Paolo, C., Seiler, T.B., Hollert, H., Froment, J., Almeida, A.C., Thomas, K.V., Tollefsen, K.E., m Tufi, S., Ouyang, X., Leonards, P., Lamoree, M., Torrens, V.O., Schriks, M., Kolkman, A.M., Spirhanzlova, P., Tindall, A., Blaha, L., Schulze, T. (2017). EDA-EMERGE – European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants with adverse effect potential in European surface waters. Sci. Total. Environ. 601-602: 1849-1868.

Almeida, A.C., Gomes, T. Langford, K., Thomas, K.V., Tollefsen, K.E. (2017). Oxidative stress in the algae Chlamydomonas reinhardtii exposed to biocides. Aquatic Toxicology. 189: 50-59.

Brockmeier, E., Hodges, G., Hutchinson, T.H., Butler, E., Hecker, M., Tollefsen, K.E., Garcia-Reyero, N., Kille, P., Becker, D., Chipman, K., Colbourne, J., Collette, T., Cossins, A., Cronin , M., Graystock, P., Gutsell, S., Knapen, D., Katsiadaki, I., Lange, A., Marshall, S. Owen, S., Perkins, E.J., Plaistow, S., Schroeder, A:, Taylor, D., Viant, M., Ankley, G., Falciani, F. (2017). The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment. Toxicological Sciences. 158 (2): 252-262.

Neale, P. A., Altenburger, R., Ait-Aissa, S., Brion, F., Busch, W., de Aragao Umbuzeiro, G., Denison, M. S., Du Pasquier, D. Hilscherova, K., Hollert, H., Morales, D. A. Novak, J. ., Schlichting, R. . Seiler, T. B., Serra, H., Shao, Y., Tindall, A. J., Tollefsen, K. E. Williams, T. D. and B. I. Escher (2017). Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water, Water Res, 123: 734-50.

Fay, K.A., Villeneuve, D.L., Lalone, C.A. Song, Y., Tollefsen, K.E., Ankley, G.T. (2017). Practical approaches to adverse outcome pathway (AOP) development and weight of evidence evaluation as illustrated by ecological case studies. Environ. Toxicol. Chem. 36(6):1429-1449.

Song, Y., Villeneuve, D.; Toyota, K.; Iguchi, T., Tollefsen, K.E. (2017). Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development. Environ. Sci. Technol., Critical reviews. 51 (8): 4142–4157

Petersen, K., Hultman, M., Tollefsen, K.E. (2017). Primary hepatocytes from Arctic char (Salvelinus alpinus) as an environmentally relevant Arctic in vitro model for screening contaminants and environmental extracts. Aquatic toxicology.187: 141–152.

Schulze, T., Ahel, M., Ahlheim, J., Aït-Aïssa, S., Brion, F., Di Paolo, C., Froment, J., Hidasi, A.O., Hollender, J., Hollert, H., Hu, M., Kloß, A., Koprivica, S., Krauss, M., Muz, M., Petre, M., Oswald, P., Schollée; J.E. Seiler, T.B., Shao, Y., Slobodnik, J., Sonavane, M., Suter, M., Tousova, Z., Tollefsen, K.E., Walz, K.H., Brack, W. (2017). Assessment of a novel device for onsite integrative large-volume solid phase extraction of water samples to enable a comprehensive chemical and effect-based analysis. Sci. Total Environment. 581-582: 350–358.

Ouyang, X., Froment, J., Leonards, P. E.G., Christiensen, G., Tollefsen, K.E., de Boer, J., Thomas, K.V., Lamoree, M.H. (2017). Miniaturization of a transthyretin binding assay using a fluorescent probe for high throughput screening of thyroid hormone disruption in environmental samples. Chemosphere. 171: 722–728.

Gomes, T., Xie, L., Brede, D., Lind, O.C., Solhaug, K.A., Salbu, B., Tollefsen, K.E. (2017). Sensitivity of the green algae Chlamydomonas reinhardtii to ionizing (gamma) radiation: photosynthetic performance and ROS formation. Aquatic Toxicology. 183:1-10.

Last updated 08.08.2022