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Knut Erik Tollefsen
dr.scient. (PhD)
Position: Chief Scientist
Phone: +47 922 18 466
Section: Økotoksikologi og risikovurdering
Email: knut.erik.tollefsen(at)niva.no
Dr. Knut Erik Tollefsen, senior scientist at Section for ecotoxicology and risk assessment has been employed at Norwegian Institute for water research (NIVA) since January 2002. He is alos workng as an Adjunct Professor in Ecotoxicology at Norwegian University of Life Sciences (NMBU) since Aug. 2006. He is an Eurotox registered ecotoxicologist with over 20 years of experience in ecotoxicology with special emphasis on ecotoxicological testing (effect assessment), biomarker research, ecotoxicogenomics, environmental monitoring, endocrine disruption, radiation, combined toxicity and risk assessment. Dr. Tollefsen is acting as an expert advisor for the Norwegian Environment Agency; participates in the OECD working and management group on non-animal testing (WMG-NA), the OECD advisory group on Molecular Screening and Toxicogenomics (EAGMST) and the EC expert advisory group on endocrine disruptors. He has extensive project management experience in national and international projects and has published over 120 scientific papers in peer-reviewed journals (h-index:37, i10-index: 74), supervised 6 Bc. Sc. students, 17 M. Sc. students, 20 PhD. students and 5 Post docs.
Search in NIVA-reports (1958 - )
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Scientific articles and Bookchapters

  1. Cao, Yang; Moe, S. Jannicke; De Bin, Riccardo; Tollefsen, Knut-Erik; Song, You; (2023) Comparison of piecewise structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network. Altex ISSN 1868-596X. Vol 40 No2 s287-298 doi: 10.14573/altex.2207113
  2. Chauhan, Vinita; Yu, Jihang; Vuong, Ngoc; Haber, Lynne T.; Williams, Andrew; Auerbach, Scott S.; Beaton, Danielle; Wang, Yi; Stainforth, Robert; Wilkins, Ruth C.; Azzam, Edouard I.; Richardson, Richard B.; Khan, Md Gulam Musawwir; Jadhav, Ashok; Burtt, Julie J.; Leblanc, Julie; Randhawa, Kristi; Tollefsen, Knut-Erik; Yauk, Carole L.; (2023) Considerations for application of benchmark dose modeling in radiation research: workshop highlights. International Journal of Radiation Biology ISSN 0955-3002. doi: 10.1080/09553002.2023.2181998
  3. Song, You; Zheng, Keke; Brede, Dag Anders; Gomes, Tania; Xie, Li; Kassaye, Yetneberk Ayalew; Salbu, Brit; Tollefsen, Knut-Erik; (2023) Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation. Environmental Science and Technology ISSN 0013-936X. Vol 57 No8 s3198-3205 doi: 10.1021/acs.est.2c04917
  4. Cao, Yang; Moe, Jannicke; De Bin, Riccardo; Tollefsen, Knut-Erik; Song, You; (2022) Comparison of structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network. Altex ISSN 1868-596X. doi: 10.14573/altex.2207113
  5. Burtt, Julie J.; Leblanc, Julie; Randhawa, Kristi; Ivanova, Addie; Rudd, Murray A.; Wilkins, Ruth; Azzam, Edouard I.; Hecker, Markus; Horemans, Nele; Vandenhove, Hildegarde; Adam-Guillermin, Christelle; Armant, Olivier; Klokov, Dmitry; Audouze, Karine; Kaiser, Jan Christian; Moertl, Simone; Lumniczky, Katalin; Tanaka, Ignacia B.; Yamada, Yutaka; Hamada, Nobuyuki; Al-Nabulsi, Isaf; Preston, R. Julian; Bouffler, Simon; Applegate, Kimberly; Cool, Donald; Beaton, Danielle; Tollefsen, Knut-Erik; Garnier-Laplace, Jacqueline; Laurier, Dominique; Chauhan, Vinita; (2022) Radiation adverse outcome pathways (AOPs) are on the horizon: Advancing radiation protection through an international Horizon-Style exercise. International Journal of Radiation Biology ISSN 0955-3002. Vol 98 No12 s1763-1776 doi: 10.1080/09553002.2022.2121439
  6. Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut-Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen; (2022) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology ISSN 0166-445X. Vol 243 doi: 10.1016/j.aquatox.2021.106058
  7. Xie, Li; Song, You; Petersen, Karina; Solhaug, Knut Asbjørn; Lind, Ole Christian; Brede, Dag Anders; Salbu, Brit; Tollefsen, Knut-Erik; (2022) Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation. Science of the Total Environment ISSN 0048-9697. Vol 846 doi: 10.1016/j.scitotenv.2022.157457
  8. Beyer, Jonny; Song, You; Tollefsen, Knut-Erik; Berge, John Arthur; Tveiten, Lise Ann; Helland, Aud; Øxnevad, Sigurd; Schøyen, Merete; (2022) The ecotoxicology of marine tributyltin (TBT) hotspots: A review. Marine Environmental Research ISSN 0141-1136. Vol 179 doi: 10.1016/j.marenvres.2022.105689
  9. Xie, Li; Macken, Ailbhe; Johnsen, Bjørn; Norli, Marit; Skogan, Odd Arne Segtnan; Tollefsen, Knut-Erik; (2022) The MicroClimate Screen – A microscale climate exposure system for assessing the effect of CO<inf>2</inf>, temperature and UV on marine microalgae. Marine Environmental Research ISSN 0141-1136. Vol 179 doi: 10.1016/j.marenvres.2022.105670
  10. Mentzel, Sophie; Grung, Merete; Holten, Roger; Tollefsen, Knut-Erik; Stenrød, Marianne; Moe, S. Jannicke; (2022) Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a bayesian network. Frontiers in Environmental Science ISSN 2296-665X. Vol 10 doi: 10.3389/fenvs.2022.957926
  11. Chauhan, Vinita; Hamada, Nobuyuki; Wilkins, Ruth; Garnier-Laplace, Jacqueline; Laurier, Dominique; Beaton, Danielle; Tollefsen, Knut-Erik; (2022) A high-level overview of the OECD AOP Development Programme. International Journal of Radiation Biology ISSN 0955-3002. Vol 98 No12 s1704-1713 doi: 10.1080/09553002.2022.2110311
  12. Jaylet, Thomas; Quintens, Roel; Benotmane, Mohamed Abderrafi; Luukkonen, Jukka; Tanaka, Ignacia Braga; Ibanez, Chrystelle; Durand, Christelle; Sachana, Magdalini; Azimzadeh, Omid; Adam-Guillermin, Christelle; Tollefsen, Knut-Erik; Laurent, Olivier; Audouze, Karine; Armant, Olivier; (2022) Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning. International Journal of Radiation Biology ISSN 0955-3002. Vol 98 No12 s1752-1762 doi: 10.1080/09553002.2022.2110312
  13. Mentzel, Sophie; Grung, Merete; Holten, Roger; Tollefsen, Knut-Erik; Stenrød, Marianne; Moe, S. Jannicke; (2022) Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a bayesian network. Frontiers in Environmental Science ISSN 2296-665X. Vol 10 doi: 10.3389/fenvs.2022.957926
  14. Mentzel, Sophie; Martínez-Megías, Claudia; Grung, Merete; Rico, Anreu; Tollefsen, Knut-Erik; Van den Brink, Paul J.; Moe, Solveig Jannicke; (2022) Using a Bayesian network model to predict effects of pesticides on aquatic community endpoints in a rice field – A southern European case study. bioRxiv - the preprint server for biology doi: 10.1101/2022.10.19.512688
  15. Bajard, Lola; Adamovsky, Ondrej; Audouze, Karine; Baken, Kirsten; Barouki, Robert; Beltman, Joost B.; Beronius, Anna; Bonefeld-Jørgensen, Eva Cecilie; Cano-Sancho, German; de Baat, Milo L.; Di Tillio, Filippo; Fernandez, Mariana F.; FitzGerald, Rex E.; Gundacker, Claudia; Hernández, Antonio F.; Hilscherova, Klara; Karakitsios, Spyros; Kuchovska, Eliska; Long, Manhai; Luijten, Mirjam; Majid, Sanah; Marx-Stoelting, Philip; Mustieles, Vicente; Negi, Chander K.; Sarigiannis, Dimosthenis; Scholz, Stefan; Sovadinova, Iva; Stierum, Rob; Tanabe, Shihori; Tollefsen, Knut-Erik; van den Brand, Annick D.; Vogs, Carolina; Wielsøe, Maria; Wittwehr, Clemens; Blaha, Ludek; (2022) Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations. Environmental Research ISSN 0013-9351. Vol 217 doi: 10.1016/j.envres.2022.114650
  16. Belfield, Samuel J.; Firman, James W.; Enoch, Steven J.; Madden, Judith C.; Tollefsen, Knut-Erik; Cronin, Mark T.D.; (2022) A review of quantitative structure-activity relationship modelling approaches to predict the toxicity of mixtures. Computational Toxicology ISSN 2468-1113. Vol 25 doi: 10.1016/j.comtox.2022.100251
  17. Tollefsen, Knut Erik; Alonzo, Frederic; Beresford, Nicholas A.; Brede, Dag Anders; Dufourcq-Sekatcheff, Elizabeth; Gilbin, Rodolphe; Horemans, Nele; Hurem, Selma; Laloi, Patrick; Maremonti, Erica; Oughton, Deborah Helen; Simon, Olivier; Song, You; Wood, Michael; Xie, Li; Frelon, Sandrine; (2022) Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network. International Journal of Radiation Biology ISSN 0955-3002. Vol 98 No12 s1816-1831 doi: 10.1080/09553002.2022.2110317
  18. Welch, Samuel Alexander Stafford; Olsen, Kristine; Nouri Sharikabad, Mohammad; Tollefsen, Knut-Erik; Grung, Merete; Moe, Solveig Jannicke; (2022) Pharmaceutical pollution: Prediction of environmental concentrations from national wholesales data. Open Research Europe ISSN 2732-5121. Vol 2 doi: 10.12688/openreseurope.14129.2
  19. Tanabe, Shihori; O'Brien, Jason; Tollefsen, Knut-Erik; Chauhan, Vinita; Yauk, Carole; Huligaga, E.; Rudel, Ruthann A.; Kay, J.E.; Helm, Jessica; Beaton, Danielle; Filipovska, Julija; Sovadinova, Iva; Garcia-Reyero, Natalia; Mally, Angela; Poulsen, P; Delrue, Nathalie; Fritsche, Ellen; Luettich, Karsta; La Rocca, Cinzia; Yepiskoposyan, Hasmik; Klose, Jennifer; Høgh Danielsen, P.; Esterhuizen, Maranda; Jacobsen, N.R.; Vogel, U; Gant, Timothy W.; Choi, I.; FitzGerald, R.; (2022) Reactive Oxygen Species in the Adverse Outcome Pathway framework: towards Creation of Harmonized Consensus Key Events. Frontiers in Toxicology Vol 4 doi: doi: 10.3389/ftox.2022.887135
  20. Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian; (2021) Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology ISSN 0166-445X. Vol 235 doi: 10.1016/j.aquatox.2021.105836
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.

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