Knut Erik Tollefsen
PhD
Position: Senior Research Scientist, Adj. Prof.
Phone: +47 922 18 466
Section: Økotoksikologi og risikovurdering
Dr. Knut Erik Tollefsen, senior scientist at Section for ecotoxicology and risk assessment has been employed at Norwegian Institute for water research (NIVA) since January 2002. He is alos workng as an Adjunct Professor in Ecotoxicology at Norwegian University of Life Sciences (NMBU) since Aug. 2006. He is an Eurotox registered ecotoxicologist with over 20 years of experience in ecotoxicology with special emphasis on ecotoxicological testing (effect assessment), biomarker research, ecotoxicogenomics, environmental monitoring, endocrine disruption, radiation, combined toxicity and risk assessment. Dr. Tollefsen is acting as an expert advisor for the Norwegian Environment Agency; participates in the OECD working and management group on non-animal testing (WMG-NA), the OECD advisory group on Molecular Screening and Toxicogenomics (EAGMST) and the EC expert advisory group on endocrine disruptors. He has extensive project management experience in national and international projects and has published over 120 scientific papers in peer-reviewed journals (h-index:37, i10-index: 74), supervised 6 Bc. Sc. students, 17 M. Sc. students, 20 PhD. students and 5 Post docs.

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Scientific articles and Bookchapters

  1. Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; Lee, YeonKyeong; Xie, Li; Alestrøm, Peter; Salbu, Brit; Tollefsen, Knut-Erik; (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research ISSN 0013-9351. Vol 190 doi: 10.1016/j.envres.2020.109930
  2. Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk Ayalew; Thaulow, Jens; Caldwell, Gary S.; Salbu, Brit; Tollefsen, Knut-Erik; (2020) Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment ISSN 0048-9697. Vol 705 doi: 10.1016/j.scitotenv.2019.135912
  3. Mellor, Claire L.; Tollefsen, Knut-Erik; LaLone, Carlie; Cronin, Mark T.D.; Firman, James W.; (2020) In silico identification of chemicals capable of binding to the ecdysone receptor. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 39 No7 s1438-1450 doi: 10.1002/etc.4733
  4. Song, You; Nahrgang, Jasmine; Tollefsen, Knut Erik; (2019) Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida). Science of the Total Environment ISSN 0048-9697. Vol 653 s176-189 doi: 10.1016/j.scitotenv.2018.10.261
  5. Almeida, Ana Catarina; Gomes, Tânia; Langford, Katherine; Thomas, Kevin V; Tollefsen, Knut Erik; (2019) Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquatic Toxicology ISSN 0166-445X. Vol 210 s117-128 doi: 10.1016/j.aquatox.2019.02.021
  6. Lindeman, Leif Christopher; Thaulow, Jens; Song, You; Kamstra, Jorke H; Xie, Li; Asselman, Jana; Aleström, Peter; Tollefsen, Knut Erik; (2019) Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics Vol 5 No3 doi: 10.1093/eep/dvz016
  7. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Brede, Dag Anders; Lind, Ole Christian; Salbu, Brit; Tollefsen, Knut Erik; (2019) Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor. Science of the Total Environment ISSN 0048-9697. Vol 680 s23-34 doi: 10.1016/j.scitotenv.2019.05.016
  8. Salbu, B; Teien, H C; Lind, O C; Tollefsen, K E; (2019) Why is the multiple stressor concept of relevance to radioecology?. International Journal of Radiation Biology ISSN 0955-3002. Vol 95 No7 s1015-1024 doi: 10.1080/09553002.2019.1605463
  9. Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut-Erik; (2019) Knowledge Graph Embedding for Ecotoxicological Effect Prediction. Ghidini, Chiara; Hartig, Olaf; Maleshkova, Maria; Svátek, Vojtěch; Cruz, Isabel; Hogan, Aidan; Song, Jie; Lefrançois, Maxime; Gandon, Fabien; Springer Kapittel 30. ISBN 978-3-030-30795-0. s490-506
  10. Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut-Erik; (2019) Knowledge graph embedding for ecotoxicological effect prediction. CEUR Workshop Proceedings ISSN 1613-0073. Vol 2456 No10 s37-40
  11. Fischer, Melanie; Belanger, Scott E; Berckmans, Pascale; Bernhard, Mary J; Bláha, Ludek; Schmid, Diana E Coman; Dyer, Scott D; Haupt, Tina; Hermens, Joop L M; Hultman, Maria T; Laue, Heike; Lillicrap, Adam David; Mlnaříková, Marie; Natsch, Andreas; Novák, Jiří; Sinnige, Theo L; Tollefsen, Knut Erik; Niederhäusern, Valentin von; Witters, Hilda; Županič, Anže; Schirmer, Kristin; (2019) Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity. Toxicological Sciences ISSN 1096-6080. Vol 169 No2 s353-364 doi: 10.1093/toxsci/kfz057
  12. Evenseth, Linn M; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt; (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology ISSN 2468-1113. Vol 12 doi: 10.1016/j.comtox.2019.100091
  13. Blagojevic, Dajana; Lee, YeonKyeong; Xie, Li; Brede, Dag A; Nybakken, Line; Lind, Ole Christian; Tollefsen, Knut Erik; Salbu, Brit; Solhaug, Knut Asbjørn; Olsen, Jorunn E; (2019) No evidence of a protective or cumulative negative effect of UV-B on growth inhibition induced by gamma radiation in Scots pine (Pinus sylvestris) seedlings. Photochemical and Photobiological Sciences ISSN 1474-905X. Vol 18 No8 s1945-1962 doi: 10.1039/c8pp00491a
  14. Hiruta, Chizue; Kakui, Keiichi; Tollefsen, Knut E.; Iguchi, Taisen; (2018) Targeted gene disruption by use of CRISPR/Cas9 ribonucleoprotein complexes in the water flea Daphnia pulex. Genes to Cells ISSN 1356-9597. Vol 23 No6 s494-502 doi: 10.1111/gtc.12589
  15. Altenburger, Rolf; Scholze, Martin; Busch, Wibke; Escher, Beate I; Jakobs, Gianina; Krauss, Martin; Krüger, Janet; Neale, Peta A.; Aït-Aïssa, Selim; Almeida, Ana Catarina; Seiler, Thomas-Benjamin; Brion, François; Hilscherová, Klára; Hollert, Henner; Novak, Jiri; Schlichting, Rita; Serra, Helene; Shao, Ying; Tindall, Andrew; Tollefsen, Knut-Erik; Umbuzeiro, Gisela de Aragão; Williams, Tim D.; Kortenkamp, Andreas; (2018) Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays. Environment International ISSN 0160-4120. Vol 114 s95-106 doi: 10.1016/j.envint.2018.02.013
  16. Song, You; Asselman, Jana; De Schamphelaere, Karel A. C.; Salbu, Brit; Tollefsen, Knut Erik; (2018) Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: A Conceptual Approach. Environmental Science and Technology ISSN 0013-936X. Vol 52 No9 s5479-5489 doi: 10.1021/acs.est.8b00749
  17. Miyakawa, Hitoshi; Sato, Tomomi; Song, You; Tollefsen, Knut Erik; Iguchi, Taisen; (2018) Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. Journal of Steroid Biochemistry and Molecular Biology ISSN 0960-0760. Vol 184 s62-68 doi: 10.1016/j.jsbmb.2017.12.006
  18. Gomes, Tania; Song, You; Brede, Dag Anders; Xie, Li; Gutzkow, Kristine Bjerve; Salbu, Brit; Tollefsen, Knut Erik; (2018) Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Science of the Total Environment ISSN 0048-9697. Vol 628-629 s206-216 doi: 10.1016/j.scitotenv.2018.02.039
  19. Tousova, Zuzana; Froment, Jean; Oswald, Peter; Slobodnik, Jaroslav; Hilscherova, Klara; Thomas, Kevin V; Tollefsen, Knut Erik; Reid, Malcolm; Langford, Katherine; Blaha, Ludek; (2018) Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques. Journal of Hazardous Materials ISSN 0304-3894. Vol 358 s494-502 doi: 10.1016/j.jhazmat.2018.05.031
  20. Xie, Li; Gomes, Tania; Solhaug, Knut Asbjørn; Song, You; Tollefsen, Knut Erik; (2018) Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. Aquatic Toxicology ISSN 0166-445X. Vol 197 s98-108 doi: 10.1016/j.aquatox.2018.02.005
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.

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