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Knut Erik Tollefsen
Position: Senior Research Scientist, Adj. Prof.
Phone: +47 922 18 466
Section: Økotoksikologi og risikovurdering
Dr. Knut Erik Tollefsen, senior scientist at Section for ecotoxicology and risk assessment has been employed at Norwegian Institute for water research (NIVA) since January 2002. He is alos workng as an Adjunct Professor in Ecotoxicology at Norwegian University of Life Sciences (NMBU) since Aug. 2006. He is an Eurotox registered ecotoxicologist with over 20 years of experience in ecotoxicology with special emphasis on ecotoxicological testing (effect assessment), biomarker research, ecotoxicogenomics, environmental monitoring, endocrine disruption, radiation, combined toxicity and risk assessment. Dr. Tollefsen is acting as an expert advisor for the Norwegian Environment Agency; participates in the OECD working and management group on non-animal testing (WMG-NA), the OECD advisory group on Molecular Screening and Toxicogenomics (EAGMST) and the EC expert advisory group on endocrine disruptors. He has extensive project management experience in national and international projects and has published over 120 scientific papers in peer-reviewed journals (h-index:37, i10-index: 74), supervised 6 Bc. Sc. students, 17 M. Sc. students, 20 PhD. students and 5 Post docs.

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Scientific articles and Bookchapters

  1. Song, You; Nahrgang, Jasmine; Tollefsen, Knut Erik; (2019) Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida). Science of the Total Environment ISSN 0048-9697. Vol 653 s176-189 doi: 10.1016/j.scitotenv.2018.10.261
  2. Almeida, Ana Catarina; Gomes, Tania; Langford, Katherine; Thomas, Kevin V; Tollefsen, Knut-Erik; (2019) Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquatic Toxicology ISSN 0166-445X. Vol 210 s117-128 doi: 10.1016/j.aquatox.2019.02.021
  3. Salbu, Brit; Teien, Hans-Christian; Lind, Ole Christian; Tollefsen, Knut-Erik; (2019) Why is the multiple stressor concept of relevance to radioecology?. International Journal of Radiation Biology ISSN 0955-3002. Vol 95 No7 s1015-1024 doi: 10.1080/09553002.2019.1605463
  4. Evenseth, Linn; Kristiansen, kurt; Song, You; Tollefsen, Knut-Erik; Sylte, Ingebrigt; (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology ISSN 2468-1113. Vol 12:100091 s1-11 doi: 10.1016/j.comtox.2019.100091
  5. Hiruta, Chizue; Kakui, Keiichi; Tollefsen, Knut E.; Iguchi, Taisen; (2018) Targeted gene disruption by use of CRISPR/Cas9 ribonucleoprotein complexes in the water flea Daphnia pulex. Genes to Cells ISSN 1356-9597. Vol 23 No6 s494-502 doi: 10.1111/gtc.12589
  6. Xie, Li; Gomes, Tania; Solhaug, Knut Asbjørn; Song, You; Tollefsen, Knut Erik; (2018) Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. Aquatic Toxicology ISSN 0166-445X. Vol 197 s98-108 doi: 10.1016/j.aquatox.2018.02.005
  7. Tousova, Zuzana; Froment, Jean; Oswald, Peter; Slobodnik, Jaroslav; Hilscherova, Klara; Thomas, Kevin V; Tollefsen, Knut Erik; Reid, Malcolm; Langford, Katherine; Blaha, Ludek; (2018) Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques. Journal of Hazardous Materials ISSN 0304-3894. Vol 358 s494-502 doi: 10.1016/j.jhazmat.2018.05.031
  8. Altenburger, Rolf; Scholze, Martin; Busch, Wibke; Escher, Beate I; Jakobs, Gianina; Krauss, Martin; Krüger, Janet; Neale, Peta A.; Aït-Aïssa, Selim; Almeida, Ana Catarina; Seiler, Thomas-Benjamin; Brion, François; Hilscherová, Klára; Hollert, Henner; Novak, Jiri; Schlichting, Rita; Serra, Helene; Shao, Ying; Tindall, Andrew; Tollefsen, Knut-Erik; Umbuzeiro, Gisela de Aragão; Williams, Tim D.; Kortenkamp, Andreas; (2018) Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays. Environment International ISSN 0160-4120. Vol 114 s95-106 doi: 10.1016/j.envint.2018.02.013
  9. Song, You; Asselman, Jana; De Schamphelaere, Karel A. C.; Salbu, Brit; Tollefsen, Knut Erik; (2018) Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: A Conceptual Approach. Environmental Science and Technology ISSN 0013-936X. Vol 52 No9 s5479-5489 doi: 10.1021/acs.est.8b00749
  10. Miyakawa, Hitoshi; Sato, Tomomi; Song, You; Tollefsen, Knut Erik; Iguchi, Taisen; (2018) Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. Journal of Steroid Biochemistry and Molecular Biology ISSN 0960-0760. Vol 184 s62-68 doi: 10.1016/j.jsbmb.2017.12.006
  11. Gomes, Tania; Song, You; Brede, Dag Anders; Xie, Li; Gutzkow, Kristine Bjerve; Salbu, Brit; Tollefsen, Knut Erik; (2018) Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Science of the Total Environment ISSN 0048-9697. Vol 628-629 s206-216 doi: 10.1016/j.scitotenv.2018.02.039
  12. Fay, Kellie A; Villeneuve, Daniel L; LaLone, Carlie; Song, You; Tollefsen, Knut Erik; Ankley, Gerald T; (2017) Practical approaches to adverse outcome pathway development and weight-of-evidence evaluation as illustrated by ecotoxicological case studies. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 36 No6 s1429-1449 doi: 10.1002/etc.3770
  13. Tousova, Zuzana; Oswald, Peter; Slobodnik, Jaroslav; Blaha, Ludek; Muz, Melis; Hu, Meng; Brack, Werner; Krauss, Martin; Di Paolo, Carolina; Tarcai, Zsolt; Seiler, Thomas-Benjamin; Hollert, Henner; Koprivica, Sanja; Ahel, Marijan; Schollée, Jennifer E.; Hollender, Juliane; Suter, Marc J.-F.; Hidasi, Anita O.; Schirmer, Kristin; Sonavane, Manoj; Ait-Aissa, Selim; Creusot, Nicolas; Brion, Francois; Froment, Jean Francois; Almeida, Ana Catarina; Thomas, Kevin V; Tollefsen, Knut Erik; Tufi, Sara; Ouyang, Xiyu; Leonards, Pim; Lamoree, Marja; Torrens, Victoria Osorio; Kolkman, Annemieke; Schriks, Merijn; Spirhanzlova, Petra; Tindall, Andrew; Schulze, Tobias; (2017) European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters. Science of the Total Environment ISSN 0048-9697. Vol 601-602 s1849-1868 doi: 10.1016/j.scitotenv.2017.06.032
  14. Bridges, Jim; Sauer, Ursula G.; Buesen, Roland; Deferme, Lize; Tollefsen, Knut Erik; Tralau, Tewes; van Ravenzwaay, Ben; Poole, Alan; Pemberton, Mark; (2017) Framework for the quantitative weight-of-evidence analysis of `omics data for regulatory purposes. Regulatory toxicology and pharmacology ISSN 0273-2300. Vol 91 sS46-S60 doi: 10.1016/j.yrtph.2017.10.010
  15. Gant, Timothy W.; Sauer, Ursula G.; Zhangc, Shu-Dong; Chorley, Brian N.; Hackermüllere, Jörg; Perdichizzif, Stefania; Tollefsen, Knut Erik; van Ravenzwaay, Ben; Yauk, Carole; Tong, Weida; Poole, Alan; (2017) A generic Transcriptomics Reporting Framework (TRF) for ‘omics data processing and analysis. Regulatory toxicology and pharmacology ISSN 0273-2300. Vol 91 sS36-S45 doi: 10.1016/j.yrtph.2017.11.001
  16. Brockmeier, Erica K.; Hodges, Geoff; Hutchinson, Thomas H.; Butler, Emma; Hecker, Marcus; Tollefsen, Knut Erik; Garcia-Reyero, Natalia; Kille, Peter; Becker, Dörthe; Chipman, Kevin; Colbourne, John K.; Collette, Timothy W.; Cossins, Andrew R.; Cronin, Marc Timothy David; Graystock, Peter; Gutsell, Steve; Knapen, Dries; Katsiadaki, Ioanna; Lange, Anke; Marshall, Stuart; Owen, Stewart F.; Perkins, Edward J.; Plaistow, Stewart; Schroeder, Anthony; Taylor, Daisy; Viant, Mark.R.; Ankley, Gerald; Falciani, Francesco; (2017) The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment. Toxicological Sciences ISSN 1096-6080. Vol 158 No2 s252-262 doi: 10.1093/toxsci/kfx097
  17. Kauffmann, Hans-Martin; Kamp, Hennicke; Fuchs, Regine; Chorley, Brian N.; Deferme, Lize; Ebbels, Timothy; Hackermüller, Jörg; Perdichizzi, Stefania; Poole, Alan; Sauer, Ursula G.; Tollefsen, Knut Erik; Tralau, Tewes; Yauk, Carole; van Ravenzwaay, Ben; (2017) Framework for the quality assurance of ’omics technologies considering GLP requirements. Regulatory toxicology and pharmacology ISSN 0273-2300. Vol 91 sS27-S35 doi: 10.1016/j.yrtph.2017.10.007
  18. Buesen, Roland; Chorley, Brian N.; da Silva Lima, Beatriz; Daston, George; Deferme, Lize; Ebbels, Timothy; Gant, Timothy W.; Goetz, Amber; Greally, John; Gribaldo, Laura; Hackermüller, Jörg; Hubesch, Bruno; Jennen, Danyel; Johnson, Kamin; Kanno, Jun; Kauffmann, Hans-Martin; Laffont, Madeleine; McMullen, Patrick; Meehan, Richard R.; Pemberton, Mark; Perdichizzi, Stefania; Piersma, Aldert H.; Sauer, Ursula G.; Schmidt, Kerstin; Seitz, Hervé; Sumida, Kayo; Tollefsen, Knut Erik; Tong, Weida; Tralau, Tewes; van Ravenzwaay, Ben; Weber, Ralf J.M.; Worth, Andrew; Yauk, Carole; Poole, Alan; (2017) Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regulatory toxicology and pharmacology ISSN 0273-2300. Vol 91 sS3-S13 doi: 10.1016/j.yrtph.2017.09.002
  19. Neale, Peta A.; Altenburger, Rolf; Aït-Aïssa, Selim; Brion, François; Busch, Wibke; Umbuzeiro, Gisela de Aragão; Denison, Michael S.; Du Pasquier, David; Hilscherová, Klára; Hollert, Henner; Morales, Daniel A.; Novák, Jiří; Schlichting, Rita; Seiler, Thomas-Benjamin; Serra, Helene; Shao, Ying; Tindall, Andrew J.; Tollefsen, Knut Erik; Williams, Timothy D.; Escher, Beate I.; (2017) Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water. Water Research ISSN 0043-1354. Vol 123 s734-750 doi: 10.1016/j.watres.2017.07.016
  20. Petersen, Karina; Hultman, Maria Thérése; Bytingsvik, Jenny; Harju, Mikael; Evenset, Anita; Tollefsen, Knut Erik; (2017) Characterizing cytotoxic and estrogenic activity of Arctic char tissue extracts in primary Arctic char hepatocytes. Journal of Toxicology and Environmental Health, Part A ISSN 1528-7394. Vol 80 No16-18 s1017-1030 doi: 10.1080/15287394.2017.1357277
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.