Knut Erik Tollefsen
dr.scient. (PhD)
Position: Chief Scientist
Phone: +47 922 18 466
Section: Økotoksikologi og risikovurdering
Dr. Knut Erik Tollefsen, senior scientist at Section for ecotoxicology and risk assessment has been employed at Norwegian Institute for water research (NIVA) since January 2002. He is alos workng as an Adjunct Professor in Ecotoxicology at Norwegian University of Life Sciences (NMBU) since Aug. 2006. He is an Eurotox registered ecotoxicologist with over 20 years of experience in ecotoxicology with special emphasis on ecotoxicological testing (effect assessment), biomarker research, ecotoxicogenomics, environmental monitoring, endocrine disruption, radiation, combined toxicity and risk assessment. Dr. Tollefsen is acting as an expert advisor for the Norwegian Environment Agency; participates in the OECD working and management group on non-animal testing (WMG-NA), the OECD advisory group on Molecular Screening and Toxicogenomics (EAGMST) and the EC expert advisory group on endocrine disruptors. He has extensive project management experience in national and international projects and has published over 120 scientific papers in peer-reviewed journals (h-index:37, i10-index: 74), supervised 6 Bc. Sc. students, 17 M. Sc. students, 20 PhD. students and 5 Post docs.

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Scientific articles and Bookchapters

  1. Chauhan, Vinita; Beaton, Danielle; Hamada, Nobuyuki; Wilkins, Ruth; Burtt, Julie; Leblanc, Julie; Cool, Donald; Garnier-Laplace, Jacqueline; Laurier, Dominique; Le, Yevgeniya; Yamada, Yukata; Tollefsen, Knut-Erik; (2022) Adverse outcome pathway: a path toward better data consolidation and global co-ordination of radiation research. International Journal of Radiation Biology ISSN 0955-3002. doi: 10.1080/09553002.2021.2020363
  2. Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian; (2021) Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology ISSN 0166-445X. Vol 235 doi: 10.1016/j.aquatox.2021.105836
  3. Schmid, Simon; Song, You; Tollefsen, Knut Erik; (2021) AOP report: Inhibition of chitin synthase 1 leading to increased mortality in arthropods. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No8 s2112-2120 doi: 10.1002/etc.5058
  4. Wolf, Raoul; Tollefsen, Knut-Erik; (2021) A Bayesian approach to incorporating spatiotemporal variation and uncertainty limits into modeling of predicted environmental concentrations from chemical monitoring campaigns. Environmental Science and Technology ISSN 0013-936X. Vol 55 No3 s1699-1709 doi: 10.1021/acs.est.0c06268
  5. Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine; (2021) Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research ISSN 0141-1136. Vol 170 doi: 10.1016/j.marenvres.2021.105434
  6. Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen; (2021) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology ISSN 0166-445X. Vol 243 doi: 10.1016/j.aquatox.2021.106058
  7. Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut Erik; (2021) Prediction of Adverse Biological Effects of Chemicals Using Knowledge Graph Embeddings. Semantic Web Journal ISSN 1570-0844. doi: 10.3233/SW-222804
  8. Mentzel, Sophie; Grung, Merete; Tollefsen, Knut-Erik; Stenrød, Marianne; Petersen, Karina; Moe, S. Jannicke; (2021) Development of a Bayesian network for probabilistic risk assessment of pesticides. Integrated Environmental Assessment and Management ISSN 1551-3777. doi: 10.1002/ieam.4533
  9. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut Erik; (2020) Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta ISSN 0032-0935. Vol 252 doi: 10.1007/s00425-020-03482-3
  10. Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut Erik; (2020) De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environmental Science and Technology ISSN 0013-936X. Vol 54 No20 s13147-13156 doi: 10.1021/acs.est.0c03794
  11. Mellor, Claire L.; Tollefsen, Knut Erik; LaLone, Carlie; Cronin, Mark TD; Firman, James W.; (2020) In Silico Identification of Chemicals Capable of Binding to the Ecdysone Receptor. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 39 No7 s1438-1450 doi: 10.1002/etc.4733
  12. Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; Lee, YeonKyeong; Xie, Li; Alestrøm, Peter; Salbu, Brit; Tollefsen, Knut Erik; (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research ISSN 0013-9351. Vol 190 doi: 10.1016/j.envres.2020.109930
  13. Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk; Thaulow, Jens; Caldwell, Gary; Salbu, Brit; Tollefsen, Knut Erik; (2020) Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment ISSN 0048-9697. Vol 705 doi: 10.1016/j.scitotenv.2019.135912
  14. Moe, S. Jannicke; Wolf, Raoul; Xie, Li; Landis, Wayne G.; Kotamäki, Niina; Tollefsen, Knut-Erik; (2020) Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling. Integrated Environmental Assessment and Management ISSN 1551-3777. Vol 17 No1 s147-164 doi: 10.1002/ieam.4348
  15. Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut-Erik; (2019) Knowledge graph embedding for ecotoxicological effect prediction. CEUR Workshop Proceedings ISSN 1613-0073. Vol 2456 No10 s37-40
  16. Fischer, Melanie; Belanger, Scott E; Berckmans, Pascale; Bernhard, Mary J; Bláha, Ludek; Schmid, Diana E Coman; Dyer, Scott D; Haupt, Tina; Hermens, Joop L M; Hultman, Maria T; Laue, Heike; Lillicrap, Adam David; Mlnaříková, Marie; Natsch, Andreas; Novák, Jiří; Sinnige, Theo L; Tollefsen, Knut Erik; Niederhäusern, Valentin von; Witters, Hilda; Županič, Anže; Schirmer, Kristin; (2019) Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity. Toxicological Sciences ISSN 1096-6080. Vol 169 No2 s353-364 doi: 10.1093/toxsci/kfz057
  17. Blagojevic, Dajana; Lee, YeonKyeong; Xie, Li; Brede, Dag A; Nybakken, Line; Lind, Ole Christian; Tollefsen, Knut Erik; Salbu, Brit; Solhaug, Knut Asbjørn; Olsen, Jorunn E; (2019) No evidence of a protective or cumulative negative effect of UV-B on growth inhibition induced by gamma radiation in Scots pine (Pinus sylvestris) seedlings. Photochemical and Photobiological Sciences ISSN 1474-905X. Vol 18 No8 s1945-1962 doi: 10.1039/c8pp00491a
  18. Salbu, B; Teien, H C; Lind, O C; Tollefsen, K E; (2019) Why is the multiple stressor concept of relevance to radioecology?. International Journal of Radiation Biology ISSN 0955-3002. Vol 95 No7 s1015-1024 doi: 10.1080/09553002.2019.1605463
  19. Almeida, Ana Catarina; Gomes, Tânia; Langford, Katherine; Thomas, Kevin V; Tollefsen, Knut Erik; (2019) Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquatic Toxicology ISSN 0166-445X. Vol 210 s117-128 doi: 10.1016/j.aquatox.2019.02.021
  20. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Brede, Dag Anders; Lind, Ole Christian; Salbu, Brit; Tollefsen, Knut Erik; (2019) Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor. Science of the Total Environment ISSN 0048-9697. Vol 680 s23-34 doi: 10.1016/j.scitotenv.2019.05.016
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.

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