Knut Erik Tollefsen
dr.scient. (PhD)
Position: Senior Research Scientist, Adj. Prof.
Phone: +47 922 18 466
Section: Økotoksikologi og risikovurdering
Dr. Knut Erik Tollefsen, senior scientist at Section for ecotoxicology and risk assessment has been employed at Norwegian Institute for water research (NIVA) since January 2002. He is alos workng as an Adjunct Professor in Ecotoxicology at Norwegian University of Life Sciences (NMBU) since Aug. 2006. He is an Eurotox registered ecotoxicologist with over 20 years of experience in ecotoxicology with special emphasis on ecotoxicological testing (effect assessment), biomarker research, ecotoxicogenomics, environmental monitoring, endocrine disruption, radiation, combined toxicity and risk assessment. Dr. Tollefsen is acting as an expert advisor for the Norwegian Environment Agency; participates in the OECD working and management group on non-animal testing (WMG-NA), the OECD advisory group on Molecular Screening and Toxicogenomics (EAGMST) and the EC expert advisory group on endocrine disruptors. He has extensive project management experience in national and international projects and has published over 120 scientific papers in peer-reviewed journals (h-index:37, i10-index: 74), supervised 6 Bc. Sc. students, 17 M. Sc. students, 20 PhD. students and 5 Post docs.

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Scientific articles and Bookchapters

  1. Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian; (2021) Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology ISSN 0166-445X. Vol 235 doi: 10.1016/j.aquatox.2021.105836
  2. Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine; (2021) Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research ISSN 0141-1136. Vol 170 doi: 10.1016/j.marenvres.2021.105434
  3. Wolf, Raoul; Tollefsen, Knut-Erik; (2021) A Bayesian approach to incorporating spatiotemporal variation and uncertainty limits into modeling of predicted environmental concentrations from chemical monitoring campaigns. Environmental Science and Technology ISSN 0013-936X. Vol 55 No3 s1699-1709 doi: 10.1021/acs.est.0c06268
  4. Schmid, Simon; Song, You; Tollefsen, Knut Erik; (2021) AOP report: Inhibition of chitin synthase 1 leading to increased mortality in arthropods. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No8 s2112-2120 doi: 10.1002/etc.5058
  5. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut Erik; (2020) Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta ISSN 0032-0935. Vol 252 doi: 10.1007/s00425-020-03482-3
  6. Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut Erik; (2020) De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environmental Science and Technology ISSN 0013-936X. Vol 54 No20 s13147-13156 doi: 10.1021/acs.est.0c03794
  7. Mellor, Claire L.; Tollefsen, Knut Erik; LaLone, Carlie; Cronin, Mark TD; Firman, James W.; (2020) In Silico Identification of Chemicals Capable of Binding to the Ecdysone Receptor. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 39 No7 s1438-1450 doi: 10.1002/etc.4733
  8. Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; Lee, YeonKyeong; Xie, Li; Alestrøm, Peter; Salbu, Brit; Tollefsen, Knut Erik; (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research ISSN 0013-9351. Vol 190 doi: 10.1016/j.envres.2020.109930
  9. Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk; Thaulow, Jens; Caldwell, Gary; Salbu, Brit; Tollefsen, Knut Erik; (2020) Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment ISSN 0048-9697. Vol 705 doi: 10.1016/j.scitotenv.2019.135912
  10. Moe, S. Jannicke; Wolf, Raoul; Xie, Li; Landis, Wayne G.; Kotamäki, Niina; Tollefsen, Knut-Erik; (2020) Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling. Integrated Environmental Assessment and Management ISSN 1551-3777. Vol 17 No1 s147-164 doi: 10.1002/ieam.4348
  11. Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut-Erik; (2019) Knowledge graph embedding for ecotoxicological effect prediction. CEUR Workshop Proceedings ISSN 1613-0073. Vol 2456 No10 s37-40
  12. Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut-Erik; (2019) Knowledge Graph Embedding for Ecotoxicological Effect Prediction. Ghidini, Chiara; Hartig, Olaf; Maleshkova, Maria; Svátek, Vojtěch; Cruz, Isabel; Hogan, Aidan; Song, Jie; Lefrançois, Maxime; Gandon, Fabien; Springer Kapittel 30. ISBN 978-3-030-30795-0. s490-506
  13. Fischer, Melanie; Belanger, Scott E; Berckmans, Pascale; Bernhard, Mary J; Bláha, Ludek; Schmid, Diana E Coman; Dyer, Scott D; Haupt, Tina; Hermens, Joop L M; Hultman, Maria T; Laue, Heike; Lillicrap, Adam David; Mlnaříková, Marie; Natsch, Andreas; Novák, Jiří; Sinnige, Theo L; Tollefsen, Knut Erik; Niederhäusern, Valentin von; Witters, Hilda; Županič, Anže; Schirmer, Kristin; (2019) Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity. Toxicological Sciences ISSN 1096-6080. Vol 169 No2 s353-364 doi: 10.1093/toxsci/kfz057
  14. Blagojevic, Dajana; Lee, YeonKyeong; Xie, Li; Brede, Dag A; Nybakken, Line; Lind, Ole Christian; Tollefsen, Knut Erik; Salbu, Brit; Solhaug, Knut Asbjørn; Olsen, Jorunn E; (2019) No evidence of a protective or cumulative negative effect of UV-B on growth inhibition induced by gamma radiation in Scots pine (Pinus sylvestris) seedlings. Photochemical and Photobiological Sciences ISSN 1474-905X. Vol 18 No8 s1945-1962 doi: 10.1039/c8pp00491a
  15. Lindeman, Leif Christopher; Thaulow, Jens; Song, You; Kamstra, Jorke H; Xie, Li; Asselman, Jana; Aleström, Peter; Tollefsen, Knut Erik; (2019) Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics Vol 5 No3 doi: 10.1093/eep/dvz016
  16. Salbu, B; Teien, H C; Lind, O C; Tollefsen, K E; (2019) Why is the multiple stressor concept of relevance to radioecology?. International Journal of Radiation Biology ISSN 0955-3002. Vol 95 No7 s1015-1024 doi: 10.1080/09553002.2019.1605463
  17. Almeida, Ana Catarina; Gomes, Tânia; Langford, Katherine; Thomas, Kevin V; Tollefsen, Knut Erik; (2019) Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquatic Toxicology ISSN 0166-445X. Vol 210 s117-128 doi: 10.1016/j.aquatox.2019.02.021
  18. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Brede, Dag Anders; Lind, Ole Christian; Salbu, Brit; Tollefsen, Knut Erik; (2019) Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor. Science of the Total Environment ISSN 0048-9697. Vol 680 s23-34 doi: 10.1016/j.scitotenv.2019.05.016
  19. Evenseth, Linn M; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt; (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology ISSN 2468-1113. Vol 12 doi: 10.1016/j.comtox.2019.100091
  20. Song, You; Nahrgang, Jasmine; Tollefsen, Knut Erik; (2019) Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida). Science of the Total Environment ISSN 0048-9697. Vol 653 s176-189 doi: 10.1016/j.scitotenv.2018.10.261
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.

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