Knut Erik Tollefsen
dr.scient. (PhD)
Position: Chief Scientist
Phone: +47 922 18 466
Section: Økotoksikologi og risikovurdering
Dr. Knut Erik Tollefsen, senior scientist at Section for ecotoxicology and risk assessment has been employed at Norwegian Institute for water research (NIVA) since January 2002. He is alos workng as an Adjunct Professor in Ecotoxicology at Norwegian University of Life Sciences (NMBU) since Aug. 2006. He is an Eurotox registered ecotoxicologist with over 20 years of experience in ecotoxicology with special emphasis on ecotoxicological testing (effect assessment), biomarker research, ecotoxicogenomics, environmental monitoring, endocrine disruption, radiation, combined toxicity and risk assessment. Dr. Tollefsen is acting as an expert advisor for the Norwegian Environment Agency; participates in the OECD working and management group on non-animal testing (WMG-NA), the OECD advisory group on Molecular Screening and Toxicogenomics (EAGMST) and the EC expert advisory group on endocrine disruptors. He has extensive project management experience in national and international projects and has published over 120 scientific papers in peer-reviewed journals (h-index:37, i10-index: 74), supervised 6 Bc. Sc. students, 17 M. Sc. students, 20 PhD. students and 5 Post docs.

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Scientific articles and Bookchapters

  1. Chauhan, Vinita; Hamada, Nobuyuki; Garnier-Laplace, Jacqueline; Laurier, Dominique; Beaton, Danielle; Tollefsen, Knut-Erik; Locke, Paul A.; (2022) Establishing a communication and engagement strategy to facilitate the adoption of the adverse outcome pathways in radiation research and regulation. International Journal of Radiation Biology ISSN 0955-3002. doi: 10.1080/09553002.2022.2086716
  2. Xie, Li; Song, You; Petersen, Karina; Solhaug, Knut Asbjørn; Lind, Ole Christian; Brede, Dag Anders; Salbu, Brit; Tollefsen, Knut-Erik; (2022) Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation. Science of the Total Environment ISSN 0048-9697. Vol 846 doi: 10.1016/j.scitotenv.2022.157457
  3. Xie, Li; Macken, Ailbhe; Johnsen, Bjørn; Norli, Marit; Skogan, Odd Arne Segtnan; Tollefsen, Knut-Erik; (2022) The MicroClimate Screen – A microscale climate exposure system for assessing the effect of CO<inf>2</inf>, temperature and UV on marine microalgae. Marine Environmental Research ISSN 0141-1136. Vol 179 doi: 10.1016/j.marenvres.2022.105670
  4. Chauhan, Vinita; Beaton, Danielle; Hamada, Nobuyuki; Wilkins, Ruth; Burtt, Julie; Leblanc, Julie; Cool, Donald; Garnier-Laplace, Jacqueline; Laurier, Dominique; Le, Yevgeniya; Yamada, Yukata; Tollefsen, Knut-Erik; (2022) Adverse outcome pathway: a path toward better data consolidation and global co-ordination of radiation research. International Journal of Radiation Biology ISSN 0955-3002. doi: 10.1080/09553002.2021.2020363
  5. Beyer, Jonny; Song, You; Tollefsen, Knut-Erik; Berge, John Arthur; Tveiten, Lise Ann; Helland, Aud; Øxnevad, Sigurd; Schøyen, Merete; (2022) The ecotoxicology of marine tributyltin (TBT) hotspots: A review. Marine Environmental Research ISSN 0141-1136. Vol 179 doi: 10.1016/j.marenvres.2022.105689
  6. Tollefsen, Knut-Erik; Brede, Dag Anders; Maremonti, Erica; Oughton, Deborah Helen; Hurem, Selma; Alonzo, Frederic; Song, You; Beresford, Nicholas A.; Dufourcq-Sekatcheff, Elizabeth; Gilbin, Rodolphe; Horemans, Nele; Laloi, Patrick; Simon, Olivier; Wood, Michael; Li, Xie; Frelon, Sandrine; (2022) Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network. International Journal of Radiation Biology ISSN 0955-3002. doi: 10.1080/09553002.2022.2110317
  7. Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian; (2021) Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology ISSN 0166-445X. Vol 235 doi: 10.1016/j.aquatox.2021.105836
  8. Schmid, Simon; Song, You; Tollefsen, Knut Erik; (2021) AOP report: Inhibition of chitin synthase 1 leading to increased mortality in arthropods. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No8 s2112-2120 doi: 10.1002/etc.5058
  9. Wolf, Raoul; Tollefsen, Knut-Erik; (2021) A Bayesian approach to incorporating spatiotemporal variation and uncertainty limits into modeling of predicted environmental concentrations from chemical monitoring campaigns. Environmental Science and Technology ISSN 0013-936X. Vol 55 No3 s1699-1709 doi: 10.1021/acs.est.0c06268
  10. Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine; (2021) Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research ISSN 0141-1136. Vol 170 doi: 10.1016/j.marenvres.2021.105434
  11. Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen; (2021) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology ISSN 0166-445X. Vol 243 doi: 10.1016/j.aquatox.2021.106058
  12. Mentzel, Sophie; Grung, Merete; Tollefsen, Knut-Erik; Stenrød, Marianne; Petersen, Karina; Moe, S. Jannicke; (2021) Development of a Bayesian network for probabilistic risk assessment of pesticides. Integrated Environmental Assessment and Management ISSN 1551-3777. doi: 10.1002/ieam.4533
  13. Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut Erik; (2021) Prediction of adverse biological effects of chemicals using knowledge graph embeddings. Semantic Web Journal ISSN 1570-0844. Vol 13 No3 s299-338 doi: 10.3233/SW-222804
  14. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut Erik; (2020) Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta ISSN 0032-0935. Vol 252 doi: 10.1007/s00425-020-03482-3
  15. Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut Erik; (2020) De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environmental Science and Technology ISSN 0013-936X. Vol 54 No20 s13147-13156 doi: 10.1021/acs.est.0c03794
  16. Mellor, Claire L.; Tollefsen, Knut Erik; LaLone, Carlie; Cronin, Mark TD; Firman, James W.; (2020) In Silico Identification of Chemicals Capable of Binding to the Ecdysone Receptor. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 39 No7 s1438-1450 doi: 10.1002/etc.4733
  17. Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; Lee, YeonKyeong; Xie, Li; Alestrøm, Peter; Salbu, Brit; Tollefsen, Knut Erik; (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research ISSN 0013-9351. Vol 190 doi: 10.1016/j.envres.2020.109930
  18. Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk; Thaulow, Jens; Caldwell, Gary; Salbu, Brit; Tollefsen, Knut Erik; (2020) Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment ISSN 0048-9697. Vol 705 doi: 10.1016/j.scitotenv.2019.135912
  19. Moe, S. Jannicke; Wolf, Raoul; Xie, Li; Landis, Wayne G.; Kotamäki, Niina; Tollefsen, Knut-Erik; (2020) Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling. Integrated Environmental Assessment and Management ISSN 1551-3777. Vol 17 No1 s147-164 doi: 10.1002/ieam.4348
  20. Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut-Erik; (2019) Knowledge graph embedding for ecotoxicological effect prediction. CEUR Workshop Proceedings ISSN 1613-0073. Vol 2456 No10 s37-40
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.

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