You Song
PhD
Position: Senior Research Scientist, PhD
Phone: +47 982 15 446
Section: Økotoksikologi og risikovurdering
Dr. You Song is an experienced experimental ecotoxicologist, bioinformatician and Adverse Outcome Pathway (AOP) developer. He is currently working as a permanent Research Scientist in the Section of Ecotoxicology and Risk Assessment at NIVA. His main competence and research interests are: ecotoxicity testing, toxicogenomics, bioinformatics, AOPs, combined effect modeling, alternatives to animal testing, in silico prediction models, high-throughput in vitro screening, mode of action (MoA) and risk assessment of pesticides, veterinary medicines, heavy metals, radionuclides, ionizing radiation and emerging contaminants. He has also been actively involved in diverse ecotoxicological research areas, such as bioaccumulation, mixture toxicity, in vitro screening, OMICS and radiation toxicology, and have worked with a broad range of ecologically relevant species, such as waterflea (Daphnia magna), marine copepods (Tisbe battagliai, Calanus finmarchicus), springtail (Folsomia candida), green algae (Chlamydomonas reinhardtii), duckweed (Lemna minor), Atlantic salmon (Salmo salar), rainbow trout (Oncorhynchus mykiss), brown trout (Salmo trutta), Arctic char (Salvelinus alpinus), polar cod (Boreogadus saida), zebrafish (Danio rerio) and Indian forest skink (Sphenomorphus indicus). He is familiar with standard regulatory toxicity testing guidelines (e.g. OECD and ISO) and has substantial experience in D. magna, C. reinhardtii, F. candida and zebrafish embryo toxicity testing.

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Scientific articles and Bookchapters

  1. Peng, Guyu; Lin, Yan; van Bavel, Bert; Li, Daoji; Ni, Jinren; Song, You; (2022) Aggregate exposure pathways for microplastics (mpAEP): An evidence-based framework to identify research and regulatory needs. Water Research ISSN 0043-1354. Vol 209 doi: 10.1016/j.watres.2021.117873
  2. Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian; (2021) Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology ISSN 0166-445X. Vol 235 doi: 10.1016/j.aquatox.2021.105836
  3. Song, You; Kamstra, Jorke H; Cao, Yang; Asselman, Jana; Anglès d'Auriac, Marc; Friberg, Nikolai; (2021) High-throughput analyses and Bayesian network modeling highlight novel epigenetic Adverse Outcome Pathway networks of DNA methyltransferase inhibitor mediated transgenerational effects. Journal of Hazardous Materials ISSN 0304-3894. Vol 408 doi: 10.1016/j.jhazmat.2020.124490
  4. Schmid, Simon; Song, You; Tollefsen, Knut Erik; (2021) AOP report: Inhibition of chitin synthase 1 leading to increased mortality in arthropods. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No8 s2112-2120 doi: 10.1002/etc.5058
  5. Song, You; Villenueve, Daniel L.; (2021) AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No11 s2959-2967 doi: 10.1002/etc.5197
  6. Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine; (2021) Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research ISSN 0141-1136. Vol 170 doi: 10.1016/j.marenvres.2021.105434
  7. Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen; (2021) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology ISSN 0166-445X. Vol 243 doi: 10.1016/j.aquatox.2021.106058
  8. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut Erik; (2020) Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta ISSN 0032-0935. Vol 252 doi: 10.1007/s00425-020-03482-3
  9. Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut Erik; (2020) De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environmental Science and Technology ISSN 0013-936X. Vol 54 No20 s13147-13156 doi: 10.1021/acs.est.0c03794
  10. Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; Lee, YeonKyeong; Xie, Li; Alestrøm, Peter; Salbu, Brit; Tollefsen, Knut Erik; (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research ISSN 0013-9351. Vol 190 doi: 10.1016/j.envres.2020.109930
  11. Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk; Thaulow, Jens; Caldwell, Gary; Salbu, Brit; Tollefsen, Knut Erik; (2020) Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment ISSN 0048-9697. Vol 705 doi: 10.1016/j.scitotenv.2019.135912
  12. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Brede, Dag Anders; Lind, Ole Christian; Salbu, Brit; Tollefsen, Knut Erik; (2019) Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor. Science of the Total Environment ISSN 0048-9697. Vol 680 s23-34 doi: 10.1016/j.scitotenv.2019.05.016
  13. Evenseth, Linn M; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt; (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology ISSN 2468-1113. Vol 12 doi: 10.1016/j.comtox.2019.100091
  14. Song, You; Nahrgang, Jasmine; Tollefsen, Knut Erik; (2019) Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida). Science of the Total Environment ISSN 0048-9697. Vol 653 s176-189 doi: 10.1016/j.scitotenv.2018.10.261
  15. Lindeman, Leif Christopher; Thaulow, Jens; Song, You; Kamstra, Jorke H; Xie, Li; Asselman, Jana; Aleström, Peter; Tollefsen, Knut Erik; (2019) Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-azacytidine. Environmental Epigenetics Vol 5 No3 doi: 10.1093/eep/dvz016
  16. Song, You; Asselman, Jana; De Schamphelaere, Karel A. C.; Salbu, Brit; Tollefsen, Knut Erik; (2018) Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: A Conceptual Approach. Environmental Science and Technology ISSN 0013-936X. Vol 52 No9 s5479-5489 doi: 10.1021/acs.est.8b00749
  17. Xie, Li; Gomes, Tania; Solhaug, Knut Asbjørn; Song, You; Tollefsen, Knut Erik; (2018) Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. Aquatic Toxicology ISSN 0166-445X. Vol 197 s98-108 doi: 10.1016/j.aquatox.2018.02.005
  18. Gomes, Tania; Song, You; Brede, Dag Anders; Xie, Li; Gutzkow, Kristine Bjerve; Salbu, Brit; Tollefsen, Knut Erik; (2018) Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Science of the Total Environment ISSN 0048-9697. Vol 628-629 s206-216 doi: 10.1016/j.scitotenv.2018.02.039
  19. Miyakawa, Hitoshi; Sato, Tomomi; Song, You; Tollefsen, Knut Erik; Iguchi, Taisen; (2018) Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. Journal of Steroid Biochemistry and Molecular Biology ISSN 0960-0760. Vol 184 s62-68 doi: 10.1016/j.jsbmb.2017.12.006
  20. Tollefsen, Knut Erik; Song, You; Høgåsen, Tore; Øverjordet, Ida Beathe; Altin, Dag; Hansen, Bjørn Henrik; (2017) Mortality and transcriptional effects of inorganic mercury in the marine copepod Calanus finmarchicus. Journal of Toxicology and Environmental Health, Part A ISSN 1528-7394. Vol 80 No16-18 s845-861 doi: 10.1080/15287394.2017.1352198
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.

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