You Song
PhD
Position: Senior Research Scientist, PhD
Phone: +47 982 15 446
Section: Økotoksikologi og risikovurdering
Dr. You Song is an experienced experimental ecotoxicologist, bioinformatician and Adverse Outcome Pathway (AOP) developer. He is currently working as a permanent Research Scientist in the Section of Ecotoxicology and Risk Assessment at NIVA. His main competence and research interests are: ecotoxicity testing, toxicogenomics, bioinformatics, AOPs, combined effect modeling, alternatives to animal testing, in silico prediction models, high-throughput in vitro screening, mode of action (MoA) and risk assessment of pesticides, veterinary medicines, heavy metals, radionuclides, ionizing radiation and emerging contaminants. He has also been actively involved in diverse ecotoxicological research areas, such as bioaccumulation, mixture toxicity, in vitro screening, OMICS and radiation toxicology, and have worked with a broad range of ecologically relevant species, such as waterflea (Daphnia magna), marine copepods (Tisbe battagliai, Calanus finmarchicus), springtail (Folsomia candida), green algae (Chlamydomonas reinhardtii), duckweed (Lemna minor), Atlantic salmon (Salmo salar), rainbow trout (Oncorhynchus mykiss), brown trout (Salmo trutta), Arctic char (Salvelinus alpinus), polar cod (Boreogadus saida), zebrafish (Danio rerio) and Indian forest skink (Sphenomorphus indicus). He is familiar with standard regulatory toxicity testing guidelines (e.g. OECD and ISO) and has substantial experience in D. magna, C. reinhardtii, F. candida and zebrafish embryo toxicity testing.

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Scientific articles and Bookchapters

  1. Mitchell, Constance A.; Burden, Natalie; Bonnell, Mark; Hecker, Markus; Hutchinson, Thomas H.; Jagla, Magdalena; LaLone, Carlie A.; Lagadic, Laurent; Lynn, Scott G.; Shore, Bryon; Song, You; Vliet, Sara M.; Wheeler, James R.; Embry, Michelle R.; (2023) New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 42 No4 s757-777 doi: 10.1002/etc.5584
  2. Cao, Yang; Moe, S. Jannicke; De Bin, Riccardo; Tollefsen, Knut-Erik; Song, You; (2023) Comparison of piecewise structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network. Altex ISSN 1868-596X. Vol 40 No2 s287-298 doi: 10.14573/altex.2207113
  3. Song, You; Zheng, Keke; Brede, Dag Anders; Gomes, Tania; Xie, Li; Kassaye, Yetneberk Ayalew; Salbu, Brit; Tollefsen, Knut-Erik; (2023) Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation. Environmental Science and Technology ISSN 0013-936X. Vol 57 No8 s3198-3205 doi: 10.1021/acs.est.2c04917
  4. Cao, Yang; Moe, Jannicke; De Bin, Riccardo; Tollefsen, Knut-Erik; Song, You; (2022) Comparison of structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network. Altex ISSN 1868-596X. doi: 10.14573/altex.2207113
  5. Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut-Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen; (2022) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology ISSN 0166-445X. Vol 243 doi: 10.1016/j.aquatox.2021.106058
  6. Xie, Li; Song, You; Petersen, Karina; Solhaug, Knut Asbjørn; Lind, Ole Christian; Brede, Dag Anders; Salbu, Brit; Tollefsen, Knut-Erik; (2022) Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation. Science of the Total Environment ISSN 0048-9697. Vol 846 doi: 10.1016/j.scitotenv.2022.157457
  7. Peng, Guyu; Lin, Yan; van Bavel, Bert; Li, Daoji; Ni, Jinren; Song, You; (2022) Aggregate exposure pathways for microplastics (mpAEP): An evidence-based framework to identify research and regulatory needs. Water Research ISSN 0043-1354. Vol 209 doi: 10.1016/j.watres.2021.117873
  8. Beyer, Jonny; Song, You; Tollefsen, Knut-Erik; Berge, John Arthur; Tveiten, Lise Ann; Helland, Aud; Øxnevad, Sigurd; Schøyen, Merete; (2022) The ecotoxicology of marine tributyltin (TBT) hotspots: A review. Marine Environmental Research ISSN 0141-1136. Vol 179 doi: 10.1016/j.marenvres.2022.105689
  9. Tollefsen, Knut Erik; Alonzo, Frederic; Beresford, Nicholas A.; Brede, Dag Anders; Dufourcq-Sekatcheff, Elizabeth; Gilbin, Rodolphe; Horemans, Nele; Hurem, Selma; Laloi, Patrick; Maremonti, Erica; Oughton, Deborah Helen; Simon, Olivier; Song, You; Wood, Michael; Xie, Li; Frelon, Sandrine; (2022) Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network. International Journal of Radiation Biology ISSN 0955-3002. Vol 98 No12 s1816-1831 doi: 10.1080/09553002.2022.2110317
  10. Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian; (2021) Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology ISSN 0166-445X. Vol 235 doi: 10.1016/j.aquatox.2021.105836
  11. Schmid, Simon; Song, You; Tollefsen, Knut Erik; (2021) AOP report: Inhibition of chitin synthase 1 leading to increased mortality in arthropods. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No8 s2112-2120 doi: 10.1002/etc.5058
  12. Song, You; Villenueve, Daniel L.; (2021) AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No11 s2959-2967 doi: 10.1002/etc.5197
  13. Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine; (2021) Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research ISSN 0141-1136. Vol 170 doi: 10.1016/j.marenvres.2021.105434
  14. Song, You; Kamstra, Jorke H; Cao, Yang; Asselman, Jana; Anglès d'Auriac, Marc; Friberg, Nikolai; (2021) High-throughput analyses and Bayesian network modeling highlight novel epigenetic Adverse Outcome Pathway networks of DNA methyltransferase inhibitor mediated transgenerational effects. Journal of Hazardous Materials ISSN 0304-3894. Vol 408 doi: 10.1016/j.jhazmat.2020.124490
  15. Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen; (2021) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology ISSN 0166-445X. Vol 243 doi: 10.1016/j.aquatox.2021.106058
  16. Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut Erik; (2020) De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environmental Science and Technology ISSN 0013-936X. Vol 54 No20 s13147-13156 doi: 10.1021/acs.est.0c03794
  17. Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; Lee, YeonKyeong; Xie, Li; Alestrøm, Peter; Salbu, Brit; Tollefsen, Knut Erik; (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research ISSN 0013-9351. Vol 190 doi: 10.1016/j.envres.2020.109930
  18. Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk; Thaulow, Jens; Caldwell, Gary; Salbu, Brit; Tollefsen, Knut Erik; (2020) Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment ISSN 0048-9697. Vol 705 doi: 10.1016/j.scitotenv.2019.135912
  19. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut Erik; (2020) Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta ISSN 0032-0935. Vol 252 doi: 10.1007/s00425-020-03482-3
  20. Evenseth, Linn M; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt; (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology ISSN 2468-1113. Vol 12 doi: 10.1016/j.comtox.2019.100091
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.

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