You Song
PhD
Position: Researcher Scientist, PhD
Phone: +47 982 15 446
Section: Økotoksikologi og risikovurdering
You Song is currently working as a postdoc and research scientist II in the section of Ecotoxicology and Risk Assessment at NIVA. His postdoc project at NIVA is to develop adverse outcome pathways (AOPs) for endocrine disrupting chemicals using an aquatic invertebrate Daphnia magna as a model. You Song has also been actively participating in a number of research projects and working with a wide range of species, including Atlantic salmon (Salmo salar), Rainbow trout (Oncorhynchus mykiss), Brown trout (Salmo trutta), Arctic char (Salvelinus alpinus), Polar cod (Boreogadus saida), Zebrafish (Danio rerio), Daphnia magna, marine copepod Calanus finmarchicus, Caenorhabditis elegans, Lemna minor and green algae Chlamydomonas reinhardtii. His main laboratory expertise is to perform RNA-based molecular analyses such as transcriptomic analysis using DNA microarrays and quantitative real-time polymerase chain reaction (qPCR). You Song’s main research interest now is to develop and use various toxicogenomics (OMICS) tools for understanding the toxic mechanisms of environmental stressors and development of AOPs for predictive ecotoxicology and ecological risk assessment (ERA).

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Scientific articles and Bookchapters

  1. Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian; (2021) Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology ISSN 0166-445X. Vol 235 doi: 10.1016/j.aquatox.2021.105836
  2. Song, You; Kamstra, Jorke H; Cao, Yang; Asselman, Jana; Anglès d'Auriac, Marc; Friberg, Nikolai; (2021) High-throughput analyses and Bayesian network modeling highlight novel epigenetic Adverse Outcome Pathway networks of DNA methyltransferase inhibitor mediated transgenerational effects. Journal of Hazardous Materials ISSN 0304-3894. Vol 408 doi: 10.1016/j.jhazmat.2020.124490
  3. Song, You; Villenueve, Daniel; (2021) AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation. Environmental Toxicology and Chemistry ISSN 0730-7268. doi: 10.1002/etc.5197
  4. Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine; (2021) Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research ISSN 0141-1136. Vol 170 doi: 10.1016/j.marenvres.2021.105434
  5. Schmid, Simon; Song, You; Tollefsen, Knut Erik; (2021) AOP report: Inhibition of chitin synthase 1 leading to increased mortality in arthropods. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No8 s2112-2120 doi: 10.1002/etc.5058
  6. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut Erik; (2020) Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta ISSN 0032-0935. Vol 252 doi: 10.1007/s00425-020-03482-3
  7. Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut Erik; (2020) De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environmental Science and Technology ISSN 0013-936X. Vol 54 No20 s13147-13156 doi: 10.1021/acs.est.0c03794
  8. Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; Lee, YeonKyeong; Xie, Li; Alestrøm, Peter; Salbu, Brit; Tollefsen, Knut Erik; (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research ISSN 0013-9351. Vol 190 doi: 10.1016/j.envres.2020.109930
  9. Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk; Thaulow, Jens; Caldwell, Gary; Salbu, Brit; Tollefsen, Knut Erik; (2020) Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment ISSN 0048-9697. Vol 705 doi: 10.1016/j.scitotenv.2019.135912
  10. Lindeman, Leif Christopher; Thaulow, Jens; Song, You; Kamstra, Jorke H; Xie, Li; Asselman, Jana; Aleström, Peter; Tollefsen, Knut Erik; (2019) Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics Vol 5 No3 doi: 10.1093/eep/dvz016
  11. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Brede, Dag Anders; Lind, Ole Christian; Salbu, Brit; Tollefsen, Knut Erik; (2019) Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor. Science of the Total Environment ISSN 0048-9697. Vol 680 s23-34 doi: 10.1016/j.scitotenv.2019.05.016
  12. Evenseth, Linn M; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt; (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology ISSN 2468-1113. Vol 12 doi: 10.1016/j.comtox.2019.100091
  13. Song, You; Nahrgang, Jasmine; Tollefsen, Knut Erik; (2019) Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida). Science of the Total Environment ISSN 0048-9697. Vol 653 s176-189 doi: 10.1016/j.scitotenv.2018.10.261
  14. Song, You; Asselman, Jana; De Schamphelaere, Karel A. C.; Salbu, Brit; Tollefsen, Knut Erik; (2018) Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: A Conceptual Approach. Environmental Science and Technology ISSN 0013-936X. Vol 52 No9 s5479-5489 doi: 10.1021/acs.est.8b00749
  15. Xie, Li; Gomes, Tania; Solhaug, Knut Asbjørn; Song, You; Tollefsen, Knut Erik; (2018) Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. Aquatic Toxicology ISSN 0166-445X. Vol 197 s98-108 doi: 10.1016/j.aquatox.2018.02.005
  16. Gomes, Tania; Song, You; Brede, Dag Anders; Xie, Li; Gutzkow, Kristine Bjerve; Salbu, Brit; Tollefsen, Knut Erik; (2018) Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Science of the Total Environment ISSN 0048-9697. Vol 628-629 s206-216 doi: 10.1016/j.scitotenv.2018.02.039
  17. Miyakawa, Hitoshi; Sato, Tomomi; Song, You; Tollefsen, Knut Erik; Iguchi, Taisen; (2018) Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. Journal of Steroid Biochemistry and Molecular Biology ISSN 0960-0760. Vol 184 s62-68 doi: 10.1016/j.jsbmb.2017.12.006
  18. Tollefsen, Knut Erik; Song, You; Høgåsen, Tore; Øverjordet, Ida Beathe; Altin, Dag; Hansen, Bjørn Henrik; (2017) Mortality and transcriptional effects of inorganic mercury in the marine copepod Calanus finmarchicus. Journal of Toxicology and Environmental Health, Part A ISSN 1528-7394. Vol 80 No16-18 s845-861 doi: 10.1080/15287394.2017.1352198
  19. Song, You; Evenseth, Linn Mari; Iguchi, Taisen; Tollefsen, Knut Erik; (2017) Release of chitobiase as an indicator of potential molting disruption in juvenile Daphnia magna exposed to the ecdysone receptor agonist 20-hydroxyecdysone. Journal of Toxicology and Environmental Health, Part A ISSN 1528-7394. Vol 80 No16-18 s954-962 doi: 10.1080/15287394.2017.1352215
  20. Song, You; Villeneuve, Daniel L.; Toyota, Kenji; Iguchi, Taisen; Tollefsen, Knut Erik; (2017) Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development. Environmental Science and Technology ISSN 0013-936X. Vol 51 No8 s4142-4157 doi: 10.1021/acs.est.7b00480
NIVA began to register scientific articles in CRIStin in 2010, reports from 2014.

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