You Song
PhD
Stilling: Seniorforsker, ph.d.
Telefon: +47 982 15 446
Seksjon: Økotoksikologi og risikovurdering
Dr. You Song is an experienced experimental ecotoxicologist, bioinformatician and Adverse Outcome Pathway (AOP) developer. He is currently working as a permanent Research Scientist in the Section of Ecotoxicology and Risk Assessment at NIVA. His main competence and research interests are: ecotoxicity testing, toxicogenomics, bioinformatics, AOPs, combined effect modeling, alternatives to animal testing, in silico prediction models, high-throughput in vitro screening, mode of action (MoA) and risk assessment of pesticides, veterinary medicines, heavy metals, radionuclides, ionizing radiation and emerging contaminants. He has also been actively involved in diverse ecotoxicological research areas, such as bioaccumulation, mixture toxicity, in vitro screening, OMICS and radiation toxicology, and have worked with a broad range of ecologically relevant species, such as waterflea (Daphnia magna), marine copepods (Tisbe battagliai, Calanus finmarchicus), springtail (Folsomia candida), green algae (Chlamydomonas reinhardtii), duckweed (Lemna minor), Atlantic salmon (Salmo salar), rainbow trout (Oncorhynchus mykiss), brown trout (Salmo trutta), Arctic char (Salvelinus alpinus), polar cod (Boreogadus saida), zebrafish (Danio rerio) and Indian forest skink (Sphenomorphus indicus). He is familiar with standard regulatory toxicity testing guidelines (e.g. OECD and ISO) and has substantial experience in D. magna, C. reinhardtii, F. candida and zebrafish embryo toxicity testing.

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Vitenskapelige artikler og bokkapitler

  1. Peng, Guyu; Lin, Yan; van Bavel, Bert; Li, Daoji; Ni, Jinren; Song, You; (2022) Aggregate exposure pathways for microplastics (mpAEP): An evidence-based framework to identify research and regulatory needs. Water Research ISSN 0043-1354. Vol 209 doi: 10.1016/j.watres.2021.117873
  2. Beyer, Jonny; Song, You; Tollefsen, Knut-Erik; Berge, John Arthur; Tveiten, Lise Ann; Helland, Aud; Øxnevad, Sigurd; Schøyen, Merete; (2022) The ecotoxicology of marine tributyltin (TBT) hotspots: A review. Marine Environmental Research ISSN 0141-1136. Vol 179 doi: 10.1016/j.marenvres.2022.105689
  3. Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut-Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen; (2022) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology ISSN 0166-445X. Vol 243 doi: 10.1016/j.aquatox.2021.106058.
  4. Tollefsen, Knut Erik; Alonzo, Frederic; Beresford, Nicholas A.; Brede, Dag Anders; Dufourcq-Sekatcheff, Elizabeth; Gilbin, Rodolphe; Horemans, Nele; Hurem, Selma; Laloi, Patrick; Maremonti, Erica; Oughton, Deborah Helen; Simon, Olivier; Song, You; Wood, Michael; Xie, Li; Frelon, Sandrine; (2022) Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network. International Journal of Radiation Biology ISSN 0955-3002. doi: 10.1080/09553002.2022.2110317
  5. Cao, Yang; Moe, Jannicke; De Bin, Riccardo; Tollefsen, Knut-Erik; Song, You; (2022) Comparison of structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network. Altex ISSN 1868-596X. doi: 10.14573/altex.2207113
  6. Xie, Li; Song, You; Petersen, Karina; Solhaug, Knut Asbjørn; Lind, Ole Christian; Brede, Dag Anders; Salbu, Brit; Tollefsen, Knut-Erik; (2022) Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation. Science of the Total Environment ISSN 0048-9697. Vol 846 doi: 10.1016/j.scitotenv.2022.157457
  7. Cao, Yang; Moe, S. Jannicke; De Bin, Riccardo; Tollefsen, Knut-Erik; Song, You; (2022) Comparison of structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network. Altex ISSN 1868-596X. doi: 10.14573/altex.2207113
  8. Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian; (2021) Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology ISSN 0166-445X. Vol 235 doi: 10.1016/j.aquatox.2021.105836
  9. Song, You; Kamstra, Jorke H; Cao, Yang; Asselman, Jana; Anglès d'Auriac, Marc; Friberg, Nikolai; (2021) High-throughput analyses and Bayesian network modeling highlight novel epigenetic Adverse Outcome Pathway networks of DNA methyltransferase inhibitor mediated transgenerational effects. Journal of Hazardous Materials ISSN 0304-3894. Vol 408 doi: 10.1016/j.jhazmat.2020.124490
  10. Schmid, Simon; Song, You; Tollefsen, Knut Erik; (2021) AOP report: Inhibition of chitin synthase 1 leading to increased mortality in arthropods. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No8 s2112-2120 doi: 10.1002/etc.5058
  11. Song, You; Villenueve, Daniel L.; (2021) AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation. Environmental Toxicology and Chemistry ISSN 0730-7268. Vol 40 No11 s2959-2967 doi: 10.1002/etc.5197
  12. Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine; (2021) Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research ISSN 0141-1136. Vol 170 doi: 10.1016/j.marenvres.2021.105434
  13. Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen; (2021) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology ISSN 0166-445X. Vol 243 doi: 10.1016/j.aquatox.2021.106058
  14. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut Erik; (2020) Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta ISSN 0032-0935. Vol 252 doi: 10.1007/s00425-020-03482-3
  15. Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut Erik; (2020) De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environmental Science and Technology ISSN 0013-936X. Vol 54 No20 s13147-13156 doi: 10.1021/acs.est.0c03794
  16. Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; Lee, YeonKyeong; Xie, Li; Alestrøm, Peter; Salbu, Brit; Tollefsen, Knut Erik; (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research ISSN 0013-9351. Vol 190 doi: 10.1016/j.envres.2020.109930
  17. Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk; Thaulow, Jens; Caldwell, Gary; Salbu, Brit; Tollefsen, Knut Erik; (2020) Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment ISSN 0048-9697. Vol 705 doi: 10.1016/j.scitotenv.2019.135912
  18. Xie, Li; Solhaug, Knut Asbjørn; Song, You; Brede, Dag Anders; Lind, Ole Christian; Salbu, Brit; Tollefsen, Knut Erik; (2019) Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor. Science of the Total Environment ISSN 0048-9697. Vol 680 s23-34 doi: 10.1016/j.scitotenv.2019.05.016
  19. Evenseth, Linn M; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt; (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Computational Toxicology ISSN 2468-1113. Vol 12 doi: 10.1016/j.comtox.2019.100091
  20. Song, You; Nahrgang, Jasmine; Tollefsen, Knut Erik; (2019) Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida). Science of the Total Environment ISSN 0048-9697. Vol 653 s176-189 doi: 10.1016/j.scitotenv.2018.10.261
NIVA begynte å registrere vitenskapelige artikler i CRIStin i 2010, rapporter fra 2014.

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